ABSTRACT
A new technique for exocrine drainage in segmental pancreatic transplantation has been developed in which the renal pelvis is anastomosed to the pancreatic capsule in an end-to-end fashion, after nephrectomy. This technique can be used only in uraemic patients without renal function. The procedure was performed on a uraemic patient who was free of major problems until his death due to an intracranial haemorrhage, 41 days after transplantation. The procedure described here would appear as a new form of drainage of the pancreatic secretions in segmental grafting, with advantages over techniques previously described.
Subject(s)
Kidney Pelvis/surgery , Pancreas Transplantation , Adult , Diabetes Mellitus, Type 1/complications , Diabetes Mellitus, Type 1/surgery , Humans , Kidney Failure, Chronic/complications , Male , Methods , Middle Aged , Nephrectomy , Uremia/complicationsABSTRACT
Female pigs, fasted overnight, received an orthotopic liver transplant. During the nonhepatic phase, both blood glycerol and plasma free fatty acid concentrations increased, returning to basal values after the transplant, indicating that the liver is the main receptor of these products released in the blood from the glyceride breakdown in peripheral fat deposits. Blood glucose level rose during the nonhepatic phase, probably due in part to the perfusion of glucosated saline received by the animals during this phase. After liver transplant, blood glucose levels progressively decreased and this effect was greatly reduced by administering L-alanine. Our data indicate that metabolic changes in the donor's liver diminish the availability of gluconeogenetic substrates immediately following transplant, while administration of exogenous alanine permits faster restoration of gluconeogenetic function in the transplanted liver.
