ABSTRACT
A switchable water-adhesive, super-hydrophobic nanowire surface is developed for the formation of functional stem cell spheroids. The sizes of hADSC spheroids are readily controllable on the surface. Our surface increases cell-cell and cell-matrix interaction, which improves viability and paracrine secretion of the spheroids. Accordingly, the hADSC spheroids produced on the surface exhibit significantly enhanced angiogenic efficacy.
Subject(s)
Nanowires , Neovascularization, Physiologic/drug effects , Palladium/chemistry , Silicon/chemistry , Spheroids, Cellular/drug effects , Stem Cells/cytology , Water/chemistry , Adhesives/chemistry , Adhesives/pharmacology , Adipose Tissue/cytology , Biomimetic Materials/chemistry , Biomimetic Materials/pharmacology , Humans , Hydrophobic and Hydrophilic Interactions , Spheroids, Cellular/cytologyABSTRACT
A gas-driven ultrafast adhesion switching of water droplets on palladium-coated Si nanowire arrays is demonstrated. By regulating the gas-ambient between the atmosphere and H2 , the super-hydrophobic adhesion is repeatedly switched between water-repellent and water-adhesive. The capability of modulating the super-hydrophobic adhesion on a super-hydrophobic surface with a non-contact mode could be applicable to novel functional lab-on-a-chip platforms.
