1.
Org Biomol Chem
; 18(47): 9606-9610, 2020 12 21.
Article
in English
| MEDLINE
| ID: mdl-33237073
ABSTRACT
The aptameric protective group strategy for the one-step regioselective transformation of aminoglycoside antibiotics was found to be compatible with diverse reagents and reaction conditions. New derivatives of neomycin B were synthesized with regioselectivities of >99%. This result extends the scope of applicability of APGs facilitating access to novel aminoglycoside derivatives.