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Org Biomol Chem ; 18(47): 9606-9610, 2020 12 21.
Article in English | MEDLINE | ID: mdl-33237073

ABSTRACT

The aptameric protective group strategy for the one-step regioselective transformation of aminoglycoside antibiotics was found to be compatible with diverse reagents and reaction conditions. New derivatives of neomycin B were synthesized with regioselectivities of >99%. This result extends the scope of applicability of APGs facilitating access to novel aminoglycoside derivatives.


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Framycetin
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