Splenic and lymph nodal involvement in sarcoidosis mimicking lymphoma on fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography.

Sarcoidosis is a multisystemic disease presenting with well-defined, bilateral, symmetric hilar and right paratracheal lymph node enlargement. Recently, fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (F-18 FDG PET/CT) has been used to stage and detect occult site of active inflammation in sarcoidosis. F-18 FDG PET/CT has become a cornerstone imaging modality in the modern lymphoma management, which can present with generalized lymphadenopathy including mediastinal. We present a case series, which shows how sarcoidosis can be a "great mimic of lymphoma" on F-18 FDG PET/CT and how histopathology is essential in diagnosing sarcoidosis and ruling out lymphoma.

Metastatic melanoma to the thyroid gland expressing somatostatin receptors-imaging with 68Ga-DOTANOC PET/CT.

Malignant melanoma is an aggressive tumor with poor prognosis that can have widespread metastases at presentation. Melanoma is known to undergo neuroendocrine differentiation. We report a case of a 60-year-old woman with malignant melanoma showing a metastatic lesion in the thyroid expressing somatostatin receptors as evident by Ga-DOTANOC PET/CT and metabolically active widespread subcutaneous metastases on F-FDG PET/CT imaging.

Is femoral uptake of Tc99m-methylene diphosphonate on bone scintigraphy in bronchogenic carcinoma an alarming sign: A case report and brief review of literature?

Detection of skeletal metastasis in patients with lung cancer is important from management point of view. We report the bone scan finding in a patient with non-small cell lung carcinoma showing isolated abnormal tracer in femur and having a characteristic appearance in computed tomography, highlighting the importance of bone scan in patients with bronchogenic carcinoma.

Ocular sarcoidosis: does (18)F-FDG PET/CT have any role?

Sarcoidosis is a multisystemic disease, which may affect almost any organ including the eyes. Recently, F-FDG PET/CT has proved to be a very useful molecular imaging method allowing to obtain a complete morphofunctional cartography of active inflammatory sites and to assess treatment response in patients with sarcoidosis. We report 2 cases of sarcoidosis where F-FDG PET/CT showed intense FDG uptake in the eye globes along with multiple enlarged mediastinal lymph nodes suggestive of active sarcoidosis with ocular involvement.