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Leukemia ; 21(6): 1285-93, 2007 Jun.
Article in English | MEDLINE | ID: mdl-17429428

ABSTRACT

Differentiation of naïve B cells into plasma cells or memory cells occurs in the germinal centers (GCs) of lymph follicles or alternatively via a GC- and T-cell-independent pathway. It is currently assumed that B-cell lymphomas correlate to normal B-cell differentiation stages, but the precise correlation of several B-cell lymphomas to these two pathways remains controversial. In the present report, we describe the junctional adhesion molecule C (JAM-C), currently identified at the cell-cell border of endothelial cells, as a new B-cell marker with a tightly regulated expression during B-cell differentiation. Expression of JAM-C in tonsils allows distinction between two CD27+ B-cell subpopulations: JAM-C- GC B cells and JAM-C+ non-germinal B cells. The expression of JAM-C in different B-cell lymphomas reveals a disease-specific pattern and allows a clear distinction between JAM-C- lymphoproliferative syndromes (chronic lymphocytic leukemia, mantle cell lymphoma and follicular lymphoma) and JAM-C+ ones (hairy cell leukemia, marginal zone B-cell lymphoma). Therefore, we propose JAM-C as a new identification tool in B-cell lymphoma diagnosis.


Subject(s)
B-Lymphocytes/cytology , Cell Adhesion Molecules/analysis , Germinal Center/cytology , Leukemia, B-Cell/diagnosis , Lymphoma, B-Cell/diagnosis , Tumor Necrosis Factor Receptor Superfamily, Member 7 , Biomarkers, Tumor , Humans , Leukemia, B-Cell/pathology , Lymphoma, B-Cell/pathology
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