ABSTRACT
Two African apes are the closest living relatives of humans: the chimpanzee (Pan troglodytes) and the bonobo (Pan paniscus). Although they are similar in many respects, bonobos and chimpanzees differ strikingly in key social and sexual behaviours, and for some of these traits they show more similarity with humans than with each other. Here we report the sequencing and assembly of the bonobo genome to study its evolutionary relationship with the chimpanzee and human genomes. We find that more than three per cent of the human genome is more closely related to either the bonobo or the chimpanzee genome than these are to each other. These regions allow various aspects of the ancestry of the two ape species to be reconstructed. In addition, many of the regions that overlap genes may eventually help us understand the genetic basis of phenotypes that humans share with one of the two apes to the exclusion of the other.
Subject(s)
Evolution, Molecular , Genetic Variation/genetics , Genome, Human/genetics , Genome/genetics , Pan paniscus/genetics , Pan troglodytes/genetics , Animals , DNA Transposable Elements/genetics , Gene Duplication/genetics , Genotype , Humans , Molecular Sequence Data , Phenotype , Phylogeny , Species SpecificityABSTRACT
The care of any critically ill infant requires special technical equipment for monitoring of cardiac and pulmonary functions including mechanical ventilators and blood gas analysers. The present paper describes the treatment of myocardial dysfunction and pulmonary distress, complicated by severe brain oedema in an infant chimpanzee admitted to an intensive care unit in the Department of Neonatology of the Children's Hospital of the University of Leipzig. The condition of the chimpanzee was diagnosed and monitored by standard clinical tooös including radiography, echocardiography, cerebral Doppler sonography and laboratory parameters. The chimpanzee was treated in close cooperation between veterinarians and paediatricians.
Subject(s)
Cardiomyopathies/veterinary , Monkey Diseases/diagnosis , Monkey Diseases/therapy , Pan troglodytes , Pulmonary Edema/veterinary , Animals , Animals, Newborn , Birth Weight , Brain Edema/therapy , Brain Edema/veterinary , Cardiomyopathies/complications , Cardiomyopathies/therapy , Echocardiography/veterinary , Intensive Care Units, Neonatal , Male , Monkey Diseases/pathology , Oxygen/administration & dosage , Pulmonary Edema/complications , Pulmonary Edema/therapy , Radiography/veterinary , Ultrasonography, Doppler/veterinaryABSTRACT
Reports on intensive care and invasive treatments of primates are scarce. Generally, there is little knowledge and experience in regard to resuscitation, cardiac support and ventilation support especially in small infants of primate species. We therefore report on our experience with respect to the successful treatment of a former small-for-date chimpanzee infant with severe cardiorespiratory distress due to pneumonia inflicted by an unknown infective agent. Treatment was primarily with analgosedation, oxygen application and dobutamine infusions. Cooperation of neonatologists and veterinarians is recommended for treatment of young primates.
