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Objectives: Levofloxacin is widely used because of its broad-spectrum antimicrobial activity and convenient dosing schedule. However, the relevance of its use in children remains to be investigated. The purpose of this study is to investigate the efficacy and safety of levofloxacin use in children with severe infections. Methods: We conducted a retrospective observational study of patients <18 years of age who received levofloxacin intravenously in the Pediatric Intensive Care Unit (PICU) of our hospital during the period between 2021 and 2022. Patient demographics, course characteristics, clinical effectiveness, and adverse event correlations were extracted through a retrospective tabular review. Results: We included 25 patients treated with 28 courses of levofloxacin. The mean age of these children treated with levofloxacin was 4.41 years. Conversion of pathogenic microbiological test results to negative after levofloxacin treatment was detected in 11 courses (39.29%). A decrease in inflammatory markers, white blood cell or C-reactive protein counts, was detected in 18 courses (64.29%). A total of 57 adverse events occurred during the treatment period, of which 21 were possibly related to levofloxacin and no adverse events were probably related to levofloxacin. Conclusion: The effectiveness of levofloxacin use in children with serious infections is promising, especially for the treatment of multidrug-resistant bacteria. Adverse events occurring during the initiation of levofloxacin therapy in children are reported to be relatively common, but in this study, only a small percentage of them were possibly related to levofloxacin, and none of them were highly possibly related to levofloxacin.
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Infectious diseases are clinically very common, among which bacterial infections are the most common ones.Therefore, antibiotics have become ones of the most widely used drugs in clinical practice.While saving lives of many infected patients, antibiotics can also lead to adverse reactions, which can cause damage to organs function in severe cases and even life-threatening.Common adverse reactions include allergic reactions and various organs damage.In this review, we aimed to focus on the evaluation of common adverse reactions and organs damage caused by antibiotics, in order to improve the prevention and treatment of adverse reactions and promote rational use of antibiotics.
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Exoelectrogenic microorganisms are the research basis of microbial electrochemical technologies such as microbial fuel cells, electrolytic cells and electrosynthesis. However, their applications are restricted in organic degradation, power generation, seawater desalination, bioremediation, and biosensors due to the weak ability of biofilm formation and the low extracellular electron transfer (EET) efficiency between exoelectrogenic microorganisms and electrode. Therefore, engineering optimization of interaction between exoelectrogenic microorganisms and electrode interface recently has been the research focus. In this article, we review the updated progress in strategies for enhancing microbe-electrode interactions based on microbial engineering modifications, with a focus on the applicability and limitations of these strategies. In addition, we also address research prospects of enhancing the interaction between electroactive cells and electrodes.
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Bioelectric Energy Sources , Biofilms , Electrodes , Electron Transport , ElectronsABSTRACT
A stochastic point location (SPL) problem aims to find a target parameter on a 1-D line by operating a controlled random walk and receiving information from a stochastic environment (SE). If the target parameter changes randomly, we call the parameter dynamic; otherwise static. SE can be 1) informative (p > 0.5 where p represents the probability for an environment providing a correct suggestion) and 2) deceptive (p <; 0.5). Up till now, hierarchical stochastic searching on the line (HSSL) is the most efficient algorithms to catch static or dynamic parameter in an informative environment, but unable to locate the target parameter in a deceptive environment and to recognize an environment's type (informative or deceptive). This paper presents a novel solution, named symmetrical HSSL, by extending an HSSL binary tree-based search structure to a symmetrical form. By means of this innovative way, the proposed learning mechanism is able to converge to a static or dynamic target parameter in the range of not only 0.6181 <; p <; 1, but also 0 <; p <; 0.382. Finally, the experimental results show that our scheme is efficient and feasible to solve the SPL problem in any SE.
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Objective To learn the epidemiological characteristics of syphilis in Shihezi in recent three years and to provide bases for prevention .Epidemiological analysis with syphilis was conducted in our hospital from 2012 to 2014 ,which is about the detection rate ,age ,gender ,and the distribution in the department .Methods Serum were deteceted by using three methods and the data were analyzed .Results 1 281 syphilis cases in 74 798 patients were detected in our hospital during this period .The total positve rate of three years was 1 .71% .The positve rate was 1 .35% ,1 .83% and 2 .01% respectively .The results of three years was significant differences(χ2 =39 .877 ,P0 .05) .The ca‐ses were mainly distributed in Han(581 ,45 .36% ) ,Uygur(43 ,3 .36% ) ,Kazak(23 ,1 .80% ) .353 cases were negative by RPR among 1 281 patients with syphilis(27 .56% ) ,and the negative rises year by year .Conclusion The incidence of syphilis increased slightly in Shihezi since 2012 .Though the detection rate between 2013 and 2014 was no significant difference .The focus was on 20- year′s old women of childbearing age .It is necessary to take strict measures to control the spread of syphilis and to do syphilis examina‐tion for all inpatients in order to prevent the infection of syphilis .
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This paper is composed with the cardiac sound measurement and analysis system for in-home use of heart abnormality monitoring. The heart sound acquiring system is composed of a traditional chest-piece, earphone, microphone, and IC recorder. The recorded data is transmitted to a computer by USB interface for analysis based on the cardiac sound characteristic waveform (CSCW) method, which is extracted from an analytical model of single degree-of-freedom (SDOF). Furthermore, the characteristic parameters [T1, T2, T11, T12] are defined by the time intervals between the crossed points of the CSCW and a threshold value (THV), which are related to the first sound and the second sound and are used for discriminating normal and abnormal heart sounds. Also, an easy-understanding graphical representation for these parameters is considered, so that, even for an inexperienced user, he or she is able to monitor his or her cardiac status easily. Finally, a case study on the abnormal/normal cardiac sounds is demonstrated to validate the usefulness and efficiency of this proposed system and the cardiac sound characteristic waveform method.
Subject(s)
Humans , Algorithms , Heart Auscultation , Heart Sounds , Physiology , Signal Processing, Computer-Assisted , Software Design , StethoscopesABSTRACT
Objective: To observe the clinical effect in the treatment of toothache by puncturing Hegu(LI 4). Methods: Two hundred and seventy-eight cases of the patients were randomly divided into the treatment group (139 cases) and the control group (139 cases). The treatment group was treated by puncturing Hegu (LI 4) with electric stimulation and the control group, by puncturing Chenshan (BL 57) with electric stimulation, for 3 days as one course of the treatment,to grade pain and observe the anesthetic effect respectively. Results: There was no significant difference in the remarkable effective rate between the two groups before withdrawal of the needle in the treatment for one day (P＞0.05). In the other times, the remarkable effective rate was obviously higher in the treatment group than in the control group (P＜0.05). Conclusion:Acupuncture on Hegu (LI 4) is effective in treating toothache.
