[Bilateral deep venous thrombosis and vena cava aplasia treated with local thrombolysis]. / Bilateral dyb venøs trombose og vena cava-aplasi behandlet med lokal trombolyse.

In this case report the treatment of a young man with bilateral iliaco-femoral DVT and vena cava aplasia is presented. The patient was treated with catheter-directed thrombolysis; the catheters were introduced in the thrombus of both legs via v. popliteae. The treatment led to almost complete thrombus resolution and no valvular incompetence at three months follow-up. In our opinion this treatment should be offered even in complex cases of acute proximal deep venous thrombosis.

[Endovascular treatment of chronic iliac vein obstruction in patients with venous claudication]. / Endovaskulaer behandling af kronisk vena iliaca-okklusion hos patienter med venøs claudicatio.

INTRODUCTION: Proximal deep venous thrombosis (DVT) often leads to venous outflow obstruction in chronic venous insufficiency (CVI). This paper presents our clinical experience with iliac vein stent placement. MATERIALS AND METHODS: Between January 2001 and November 2004 balloon dilation and stent placement for the relief of iliac vein obstruction was intended in ten patients suffering from venous claudication. Median age was 35 years (range 21-42). Eight patients had earlier been treated for proximal DVT on the left side and two patients had May-Thurner syndrome. Ultrasound scanning was performed on all patients for the detection of iliac vein obstruction. It was a requirement that all patients had an open deep venous system without reflux distally to the occlusion. The procedure was carried out under local anaesthesia and all patients were anticoagulated postoperatively. RESULTS: There was one technical failure and nine patients were treated successfully. In one of these patients the stent rethrombosed after two days but the thrombus was lysed and the patient was restented more distally. All patients were discharged with an open venous system. At follow-up, eight of the nine stents were patent. Five patients had normal walking distance and three had improved. The median follow-up time was 32.5 months (range 6-53 months). CONCLUSION: The correction of iliac vein obstruction with the placement of stents in patients with venous claudication seems to be an effective, safe method which is minimally invasive. Short term patency is satisfactory but the long term results of stents in the venous system are not known and longer follow-up is required.

[Subintimal angioplasty of long femoropopliteal artery occlusions]. / Subintimal angioplastik af lange femoropopliteale arterieokklusioner.

INTRODUCTION: Subintimal angioplasty is a newer method in the treatment of lower extremity atherosclersosis. This paper reports the results of our first experiences with long (>10 cm) femoropopliteal artery occlusions. MATERIALS AND METHODS: In the period from July 1999 to July 2003, 28 patients were treated with subintimal angioplasty. The indication was intermittent claudication or critical ischaemia. The patients were followed clinically to evaluate the patency. The results are reported retrospectively. RESULTS: The technical success rate was 25/28 (89%). Patients with intermittent claudication experienced relief of symptoms after the intervention, and their median ankle-brachial index increased significantly. The primary patency rate for patients with intermittent claudication treated successfully was 53% after one year. Critical ischaemia was associated with a lower patency rate. CONCLUSION: Subintimal angioplasty can be used in the treatment of long (>10 cm) femoropopliteal artery occlusions with a high technical success rate. Our patency rates are comparable with those recorded in the literature but are still lower than those after distal bypass surgery. Thus, subintimal angioplasty may be used in treatment of patients for whom open vascular surgery is impossible or as a bridge to open vascular surgery in young patients with severe intermittent claudication.

[Local thrombolysis in proximal deep venous thrombosis of the lower extremity]. / Lokal trombolyse ved proksimal dyb venetrombose i underekstremiteten.

INTRODUCTION: Deep venous thrombosis (DVT) often leads to chronic venous insufficiency and the present study was conducted in order to investigate the effectiveness of catheter-directed thrombolysis in patients with proximal DVT of the lower extremity (iliac vein involved), with respect to recanalisation and maintenance of venous valve function. MATERIAL AND METHODS: A prospective clinical investigation was carried out with puncture of the popliteal vein for continuous infusion of r-alteplase. Twelve patients suffering from recent proximal DVT were treated: In 10 patients the left extremity was affected, in two the right. Three of the 12 patients had factor V Leiden mutation in the heterozygote form, one of whom also had prothrombin mutation in heterozygote form. RESULTS: Ten of the 12 had their venous thrombosis successfully lysed and were discharged with an open venous system in the affected limb. The lysed venous segments remained patent in all ten, with normal venous valve function, as evaluated by Doppler reflux testing. The median follow-up time was five months (range 0-9 months). In one patient, the proximal thrombus (iliac) was lysed successfully, but the femoral vein could not be opened, probably because of an old thrombus remaining from a previous DVT episode. In the other patient, the venous thrombus was lysed successfully, but the vein rethrombosed after one day. DISCUSSION: Catheter-directed thrombolysis appears feasible in patients with recent proximal DVT and the short-term results are good in terms of venous patency and valve function. A randomised trial is necessary to test whether this treatment modality is superior to conventional anticoagulation therapy.