Overweight of adolescent girls is associated with self-mutilative behavior.

BACKGROUND: The purpose of the present study was to examine the association of overweight with suicide ideation, self-mutilative behavior (SMB) and suicide attempts among underage psychiatric inpatient adolescents. SAMPLING AND METHODS: Data were collected from 439 adolescents (age = 12-17 years) admitted to psychiatric hospitalization between April 2001 and March 2006. Information on adolescents' suicidal behavior and psychiatric DSM-IV diagnoses was obtained by using the Schedule for Affective Disorder and Schizophrenia for School-Age Children. An adolescent was defined as overweight if his/her BMI exceeded the 85th percentile BMI in the age- and sex-matched Finnish population. RESULTS: Compared to adolescents without overweight, a 2.5-fold likelihood for SMB was found among overweight girls, but not among boys. CONCLUSIONS: Low self-esteem, depression or dysfunctional emotion regulation may be possible mediating factors between overweight and SMB.

Metabolic and steroidogenic alterations related to increased frequency of polycystic ovaries in women with a history of gestational diabetes.

The prevalence of polycystic ovaries (PCO) and clinical, endocrine, and metabolic features were investigated in women with previous gestational diabetes (GDM). Thirty-three women with a history of GDM and 48 controls were studied. Glucose and insulin secretion capacity was evaluated by means of the oral glucose tolerance test (OGTT), and insulin action was determined by means of a euglycemic insulin clamp. Compared with control women, women with previous GDM more often had significantly abnormal OGTT, a higher prevalence of PCO (39.4% vs. 16.7%; P = 0.03), higher serum concentrations of cortisol, dehydroepiandrosterone, and dehydroepiandrosterone sulfate and a greater area under the glucose curve. Women with previous GDM showed a lowered early phase insulin response to glucose and impaired insulin sensitivity, which was accounted for mainly by decreased glucose nonoxidation. They also demonstrated a significantly lower fasting serum C peptide/insulin ratio than the controls, indicating that women with previous GDM have impaired hepatic insulin extraction, which tended to be more marked among women with PCO. This may explain why women with PCO and previous GDM were significantly more hyperinsulinemic than women with normal ovaries. In conclusion, our data demonstrate that women with previous GDM often have PCO and abnormal OGTT. They are insulin resistant as a result of lowered glucose nonoxidation and show inappropriately low insulin responses to glucose, reflecting impaired beta-cell function. They also have higher adrenal androgen secretion, which may be associated with abdominal obesity.