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J Antibiot (Tokyo) ; 60(3): 216-9, 2007 Mar.
Article in English | MEDLINE | ID: mdl-17446696

ABSTRACT

Seven new related compounds named bispolides A1, A2, A3, B1, B2a, B2b and B3, have been found in a culture of Microbispora sp. A34030, isolated from a Malaysian soil sample. The planar structures were elucidated to be new 20-membered ring macrodiolide antibiotics on the basis of MS and NMR spectroscopic analyses. These antibiotics showed a good anti-MRSA activity in vitro.


Subject(s)
Actinomycetales/metabolism , Anti-Bacterial Agents/chemistry , Macrolides/chemistry , Actinomycetales/growth & development , Anti-Bacterial Agents/isolation & purification , Anti-Bacterial Agents/pharmacology , Humans , Macrolides/isolation & purification , Macrolides/pharmacology , Magnetic Resonance Spectroscopy , Methicillin Resistance , Microbial Sensitivity Tests , Molecular Structure , Staphylococcus aureus/drug effects
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