Effect of Three Different Liquid Medias in the Sorption and Solubility of Luting Cements: An In Vitro Study.

Background Among the various mechanical and biological properties of luting cement, the most important are its resistance to disintegration, degradation, and stability in the oral cavity. The sorption and solubility of cement alter the mechanical properties by impeding the half-life of the filling. It also leads to variations in dimensions, discoloration, and margin breakage. It is, therefore, essential to choose a low-solubility cement since there is always an interaction between teeth and restorative margins. The aim of this study is to assess and compare the solubility and sorption values of three different luting cements in three liquid media. Materials and methods Three luting cements were used for the investigation. Disc-shaped specimens of the cement, which were of 10 mm diameter and 2 mm height, were prepared. The sample included a total of 126 disc-shaped specimens made up of three materials, glass ionomer cement (GIC), resin cement, and resin-modified GIC, which were used in three liquid media (14 of each material in each medium). Fourteen specimens of each material were placed in glass vials containing 20 ml of each medium: distilled water, artificial saliva, and carbonated water. The samples were then put in an incubator at 37 °C. The measurements and masses of the samples were documented on days one, three, seven, 14, 21, 28, and 35. The samples were taken out of the solution after five weeks and stored in a desiccator with calcium sulphate for another five weeks. The weight and dimensional changes were estimated on days one, three, seven, 14, 21, 28, and 35. The values of water sorption (WSO) and solubility (WSL) were estimated. To determine the mean and standard deviation of each cohort, descriptive statistics were employed. Utilizing the Shapiro-Wilkinson test, the normality was determined. An independent test was used to determine the difference between all pairs of groups, while one-way ANOVA, Dunn test, and post hoc analysis were used to establish the distinction between the three groups. Results One-way ANOVA showed that significant differences existed among the groups: resin cement showed the least sorption and solubility, resin-modified GIC showed the highest solubility in distilled water (0.40 ± 0.03), and GIC showed the highest solubility in both artificial saliva (0.36 ± 0.03) and carbonated water (0.04 ± 0.05). Conclusion Considering the experimental outcomes and the limitations of an in vitro investigation, it was concluded that in the complex setting of the oral environment, this selection procedure is crucial for maintaining mechanical strength and for the long lifespan of dental restorations.

Treatment of H. pylori infection and gastric ulcer: Need for novel Pharmaceutical formulation.

Peptic ulcer disease (PUD) is one of the most prevalent gastro intestinal disorder which often leads to painful sores in the stomach lining and intestinal bleeding. Untreated Helicobacter pylori (H. pylori) infection is one of the major reasons for chronic PUD which, if left untreated, may also result in gastric cancer. Treatment of H. pylori is always a challenge to the treating doctor because of the poor bioavailability of the drug at the inner layers of gastric mucosa where the bacteria resides. This results in ineffective therapy and antibiotic resistance. Current treatment regimens available for gastric ulcer and H. pylori infection uses a combination of multiple antimicrobial agents, proton pump inhibitors (PPIs), H2-receptor antagonists, dual therapy, triple therapy, quadruple therapy and sequential therapy. This polypharmacy approach leads to patient noncompliance during long term therapy. Management of H. pylori induced gastric ulcer is a burning issue that necessitates alternative treatment options. Novel formulation strategies such as extended-release gastro retentive drug delivery systems (GRDDS) and nanoformulations have the potential to overcome the current bioavailability challenges. This review discusses the current status of H. pylori treatment, their limitations and the formulation strategies to overcome these shortcomings. Authors propose here an innovative strategy to improve the H. pylori eradication efficiency.

The Evaluation of the Relationship Between Intercondylar and Intercanine Distances, Maxillary Central Incisor Width, and Various Facial Forms: A Comparative Study.

Background The intercondylar distance is a predictable and invariable parameter, which is not influenced by the soft tissue limitations and resorption unlike comparable anatomical markers. Limited studies are available on the use of intercondylar distance for the selection of teeth arrangement and its relationship with varying face forms. Aim The study aimed to evaluate the relationship between intercondylar distance and maxillary intercanine tip distances and central incisor width in square, tapering, and ovoid facial forms. Materials and methods The comparative cross-sectional study was performed between January 2021 and August 2022. A convenience sampling strategy was used to include subjects between the ages of 18 and 40 years who had all of their natural teeth. The facial forms of the subjects were detected using a face form indicator and grouped into ovoid (group A), tapering (group B), and square (group C) forms comprising 63 subjects in each group. The intercondylar and intercanine distances and maxillary central incisor width were measured using a digital caliper. The Statistical Package for Social Sciences (SPSS) software (IBM SPSS Statistics, Armonk, NY) was employed to determine the statistical difference between and across the groups using one-way analysis of variance (ANOVA) and post hoc analysis, respectively. The correlation between the variables was determined by the Pearson correlation test. Results The average age of the subjects was 24.55±3.47 years, and the age distribution was found to be statistically insignificant between the groups (p=0.63). The study consisted of 21% of males and 79% of females. The mean intercondylar distance was 125.2 mm in ovoid, 123.1 mm in tapering, and 125.9 mm in square face forms (p<0.01). The mean intercanine distance was 34.82 mm for ovoid, 37.11 mm for tapering, and 37.04 mm for square facial forms (p<0.01). Similarly, the mean central incisor width was 9, 7.84, and 8.51 mm for ovoid, tapering, and square facial forms, respectively (p<0.01). The ratio of intercondylar and intercanine distances in ovoid, tapering, and square faces was 1:3.59, 1:3.31, and 1:3.39, respectively. The ratio of intercondylar and central incisor width was 1:13.9, 1:15.7, and 1:14.7 for the groups A, B, and C, respectively. There was a statistically significant negative correlation between square and ovoid incisor width, square intercanine and ovoid incisor width, tapering incisor width and intercondylar distance, tapering intercanine and intercondylar distances, and tapering incisor width and square intercanine distance. The relationship between intercondylar and intercanine distances and the central incisor width was also revealed to be statistically highly significant (p<0.01). Conclusion When face form is taken into account, tapering face form shows more positive result for the relationship of intercondylar distance with intercanine distance and central incisor width. In patients with edentulous conditions, the intercondylar distance may offer useful measurements for tooth selection.

Effect of Preoperative Sarcopenia, Malnutrition and Functional status on Postoperative Morbidity Following Liver Transplantation.

INTRODUCTION: The effect of sarcopenia, malnutrition, and functional status on immediate post liver transplantation outcome is not well established. Most studies on sarcopenia are related to 1 and 3-year mortality. Studies evaluating the effect of malnutrition are at least a decade old. PROJECT AIMS: We evaluated the effect of preoperative sarcopenia, malnutrition, and functional status on postoperative length of hospital and ICU stay, incidence of complications, and mortality. DESIGN: In this prospective study conducted on living donor liver transplant recipients, sarcopenia and malnutrition were identified using the psoas muscle thickness to height and the Royal Free Hospital- Nutritional Prioritizing Tool respectively. The Eastern Cooperative Oncology Group performance status score was noted. Postoperatively, length-of-hospital stay, ICU stay, duration of mechanical ventilation and incidence of postoperative complications were noted. RESULTS: Hospital and ICU length of stay, and duration of mechanical ventilation were greater in sarcopenic versus non-sarcopenic patients (35.9 (14.6) versus 26.7 (10.7) days, P = 0.02; 12.9 (4.8) versus 9.6 (3.8) days, P = 0.02 and 8 [5,23] versus 5 [4,7] days, P = 0.01 respectively). The incidence of acute kidney injury was higher in patients with sarcopenia (53.3% vs 19.4%, P = 0.02). Patients with malnutrition and repeated hospitalizations had higher ICU stays but hospital length of stay duration of mechanical ventilation or the incidence of postoperative complications were not affected. The Eastern Cooperative Oncology Group score did not affect postoperative outcome. CONCLUSION: In living donor liver transplant recipients, sarcopenia increased hospital and ICU stays, and duration of mechanical ventilation postoperatively. Malnutrition increased ICU stays.

Mechanistic targets for BPH and prostate cancer-a review.

All men, almost, suffer from prostatic disorders in average life expectancy. In the year of 1950s, the first autopsy of prostate gland discovered the link between Benign prostatic hyperplasia (BPH) and Prostate Cancer (PCa). After that, many histology, biochemistry, epidemiology studies explained the association and associated risk factor for the same. From the various scientific evidence, it is proved that both diseases share some common transcription factors and signalling pathways. Still, BPH cannot be considered as the first step of PCa progression. To define, the relationship between both of the diseases, a well-defined large epidemiological study is needed. Along with androgen signalling, imbalanced apoptosis, oxidative stress, and microbial infection also crucial factors that significantly affect the pathogenesis of BPH. Various signalling pathways are involved in the progression of BPH. Androgen signalling is the driving force for the progress of PCa. In PCa androgen signalling is upregulated as compared to a healthy prostate. Some dominant Androgen-regulated genes and their functions have been discussed in this work.

Hypoglycaemic effects of alcoholic root extract of Borassus flabellifer (Linn.) in normal and diabetic rats.

The objective of the study was to investigate the alcoholic (ALEBF) extract of B. flabellifer for their hypoglycaemic effects in normal and diabetic rats. Diabetes was induced in rats by single dose administration of alloxan (120 mg/kg, i.p.) or by injecting dexamethasone (10 mg/kg, i.p.) for 10 days. In normal rats, ALEBF (100, 200 and 400 mg/kg) had significantly decreased the blood glucose level in a dose dependent manner after repeated administration for 7 days. In alloxan induced diabetic rats, extract (ALEBF) had decreased blood sugar level and improved glucose tolerance in alloxan induced diabetic rats at the end of 1st, 2nd , 3rd and 4th week after test extract treatment. However, the insulin levels of extract treated group did not significantly change after 28 days treatment with the extract. It did not alter the insulin levels. In alloxan model, repeated dose administration of ALEBF had showed significant increase in body weight, prevention of elimination of sugar in urine and reduced the mortality rate induced by alloxan. In dexamethasone induced insulin resistance diabetic rats, repeated administration of ALEBF inhibited the increase in blood glucose level, improved glucose tolerance and reduced the insulin levels as compared dexamethasone induced diabetic rats.