Unused, expired pharmaceuticals and their disposal practices among the general public in Burdur-Türkiye: a cross-sectional study.

BACKGROUND: Unused pharmaceuticals are currently a public health problem. This study aimed to identify unused pharmaceuticals, research practices about the disposal methods, classify the medicines according to Anatomical Therapeutic Chemical codes (ATC) and, to determine the number of unused medicines. METHODS: The study was designed as a cross-sectional study. Data were collected between April and August 2023 in Burdur-Türkiye by non-probability sampling technique (convenience method). Pharmaceuticals were classified according to ATC. Statistical Package for Social Science SPSS (V.24) package program was used for data analysis. RESULTS: A total of 1120 people, 1005 in the first sample group and 115 in the second sample group, participated in the study. Findings of first sample group: A total of 4097 boxes of unused pharmaceuticals (4.7 ± 4.3 boxes/per capita) were detected. It was found that pharmaceuticals were stored in areas such as kitchens (59.1%) and refrigerators (38.6%), the reason for keeping them was reuse (41%), and the disposal practice was household garbage (81%). Paracetamol (648 boxes), Other cold preparation (303 boxes), Dexketoprofen (239 boxes), Diclofenac (218 boxes), Amoxicillin and beta-lactamase inhibitor (190 boxes) were found to be the most frequently unused pharmaceuticals. Using the unused medicines at home without consulting a physician was 94.1% (self-medication). Findings of second sample group: Of the 6189 dosage forms in 265 boxes pharmaceutical, 3132(50.6%) dosage forms were used and 3057(49.4%) were found to be unused. CONCLUSION: There is a significant amount and number of unused medicines in households, and self-medication is common. Medicines are not properly disposed of and some of them expire. Public information is needed. A "drug take-back system" for unused medicines can be useful in solving this problem.

The effect of psychological distresses caused by COVID19 in healthcare professionals on happiness.

Background and Objective: COVID-19 has been negatively affecting the world for a long time. This situation can trigger mental problems such as uncertainty, anxiety, stress and depression throughout the society. The aim of our study was to search the effect of the psychological distresses caused by the COVID-19 pandemic on healthcare workers (HCWs) on happiness. Methods: This study was conducted as a descriptive and cross-sectional study in a medical school hospital in Isparta-Turkey and the data for it were collected between January and March 2022. Sociodemographic form, Coronavirus Anxiety Scale (CAS), Covid-19 Related Psychological Distress Scale (CORPD) and Oxford Happiness Questionnaire Short Form (OHQ-SF) were used for the data collection. Results: A total of 326 people, including 62(19%) physicians, 127(39%) nurses, 39(12%) officers and 98(30%) others, participated in the study. Between OHQ-SF and CAS, it was found to be r2=0.008, f=2.76 and p=0.098. Between OHQ-SF and CORPD, it was found to be r2=0.11, f=3.55 and p=0.06. Conclusion: In the HCWs, it was found that CORPD was related with the variables of gender and get vaccinated, CAS was related with the variables of economic status, profession and get COVID-19, and OHQ-SF was related with economic and marital status. It was found that anxiety and psychological distress did not affect the level of happiness. It is recommended to follow up the negative effects of the pandemic, such as anxiety, fear on the future lives, professional functions, and family life of the HCW.

Effects of synthetic (JWH-018) cannabinoids treatment on spermatogenesis and sperm function.

JWH-018 is a synthetic cannabinoid which has been increasingly used by adolescents and adults, and is known to cause severe multi-organ failure. However, little is known about the complications and toxicological effects of JWH-018 on reproduction system. Therefore, the aim of the present study is to investigate the effects of JWH-018 on testis and spermatogenesis. Thirty CD-1 male rats were distributed into six groups, control group (C1 and C2), ethanol group (E1 and E2), and JWH-018 group (JWH1 and JWH2), which were administered 0.9% NaCl, %100 ethanol, and JWH-018 (0.3 mg/kg) respectively for 9 d. We euthanized C1, E1, and JWH1 group mice at day 2 and C2, E2, and JWH2 group mice at 45 d after the last injection to evaluate the acute testis damage and potential recovery of spermatogenesis. The histopathology of seminiferous epithelium was evaluated and organ weight, sperm concentration and motility, membrane integrity, and serum testosterone levels were statistically analyzed. In JWH1, seminiferous tubule degeneration, partial germ cell depletion disorganized seminiferous epitheliums were seen. We also observed significantly decreased sperm concentration, sperm motility, intact membrane, and testosterone levels in JWH1 group compared to other groups. Forty-five days after the JWH-018 treatment, sperm concentration, motility, and testosterone level were increased, suggesting that testis and spermatogenesis can recover. We concluded that the use of JWH-018 may adversely affect male reproductive potential and testis histopathology.