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1.
Int Ophthalmol ; 44(1): 59, 2024 Feb 12.
Article in English | MEDLINE | ID: mdl-38345673

ABSTRACT

PURPOSE: To investigate the relationship between prolonged face mask use and ocular surface health utilizing conjunctival impression cytology, the Schirmer test, the tear break-up time (TBUT) test, and the ocular surface disease index (OSDI) questionnaire. METHODS: In this cross-sectional prospective study, individuals who used face masks for at least eight hours per day for at least six months were compared to healthy volunteers who used face masks for no more than one hour per day. Each participant completed an OSDI questionnaire. The Schirmer test (under anesthesia), the TBUT test, and conjunctiva impression cytology analysis according to the Nelson classification method were performed on each participant. RESULTS: This study included 102 (49 male, 53 female) face mask users with an average age of 33.29 ± 7.71 years and 110 (60 male, 50 female) healthy controls with an average age of 32.96 ± 7.10 years (p = 0.746). The total OSDI score was significantly higher in face mask users than the control group (25.18 ± 3.54 vs 9.46 ± 2.13, p < 0.001). The mean Schirmer test value and TBUT were significantly lower in the study group than the control group (p < 0.001, p < 0.001). There was a statistically significant difference between the two groups in total score and stage of the Nelson classification system (p < 0.001, and p = 0.024, respectively). All conjunctiva impression cytology assessments, including cellularity, cell-cell contact, nucleus/cytoplasma ratio, goblet cell amount, and metaplasia, revealed statistically significant deterioration in the study group compared to the control group (p < 0.001, p = 0.025, p < 0.001, p < 0.001, and p < 0.001, respectively). CONCLUSION: The prolonged use of face masks leads to dry eyes. The findings of conjunctiva impression cytology indicate the role of inflammation in the pathogenesis of mask associated dry eye.


Subject(s)
COVID-19 , Dry Eye Syndromes , Humans , Male , Female , Adult , Prospective Studies , Cross-Sectional Studies , Cytology , Masks/adverse effects , Pandemics , COVID-19/epidemiology , COVID-19/complications , Conjunctiva/pathology , Dry Eye Syndromes/diagnosis , Dry Eye Syndromes/epidemiology , Dry Eye Syndromes/etiology , Tears
2.
Photodiagnosis Photodyn Ther ; 43: 103724, 2023 Sep.
Article in English | MEDLINE | ID: mdl-37517426

ABSTRACT

BACKGROUND: Obesity is known to be a significant risk factor for many ocular diseases. In order to understand the mechanism of obesity-related ocular diseases, we examined the lamina cribrosa morphology, peripapillary choroidal thickness (PPCT), and macular choroidal thickness (MCT) in obese women using optical coherence tomography (OCT). METHODS: This comparative cross-sectional study included the right eyes of 72 obese women and 63 healthy women classified based on body mass index (BMI). Each participant underwent a thorough ophthalmological examination and enhanced depth (EDI) OCT imaging, including measurements of PPCT from a total of 12 regions, MCT from a total of 7 regions, Bruch's membrane opening (BMO), lamina cribrosa thickness (LCT), lamina cribrosa depth (LCD), intraocular pressure (IOP), and central corneal thickness (CCT). RESULTS: The mean age and BMI of the obese group were 32.36±7.38 years and 35.11±4.39 kg/m², while those of the control group were 31.64±7.78 years and 20.88±1.72 kg/m² (p = 0.658, and p<0.001, respectively). PPCT N1000, PPCT N1500, PPCT S1500, and PPCT T1500 were statistically significantly thinner in the obese group than the control group (p values were 0.039, 0.012, 0.027, and 0.036, respectively). IOP and CCT were significantly higher in the obese group than the control group (p = 0.016, and p = 0.019, respectively). There was no statistically significant difference between the two groups in terms of MCT, BMO, LCT, and LCD. CONCLUSION: We discovered thinning in the PPCT, which indicates microvascular abnormalities in the optic disc head. Microvascular alteration in the peripapillary region may be a potential initial event in the pathogenesis of several obesity-related ocular diseases, especially glaucoma.


Subject(s)
Photochemotherapy , Humans , Female , Cross-Sectional Studies , Photochemotherapy/methods , Photosensitizing Agents , Choroid/diagnostic imaging , Choroid/pathology , Tomography, Optical Coherence/methods , Obesity/complications
3.
Turk J Ophthalmol ; 53(3): 161-168, 2023 06 21.
Article in English | MEDLINE | ID: mdl-37345311

ABSTRACT

Objectives: To analyze the effect of macular choroidal thickness (MCT) and peripapillary choroidal thickness (PPCT) on the classification of obese and healthy children by comparing the performance of the random forest (RF), support vector machine (SVM), and multilayer perceptrons (MLP) algorithms. Materials and Methods: Fifty-nine obese children and 35 healthy children aged 6 to 15 years were studied in this prospective comparative study using optical coherence tomography. MCT and PPCT were measured at distances of 500 µm, 1,000 µm, and 1,500 µm from the fovea and optic disc. Three different feature selection algorithms were used to determine the most prominent features of all extracted features. The classification efficiency of the extracted features was analyzed using the RF, SVM, and MLP algorithms, demonstrating their efficacy for distinguishing obese from healthy children. The precision and reliability of measurements were assessed using kappa analysis. Results: The correlation feature selection algorithm produced the most successful classification results among the different feature selection methods. The most prominent features for distinguishing the obese and healthy groups from each other were PPCT temporal 500 µm, PPCT temporal 1,500 µm, PPCT nasal 1,500 µm, PPCT inferior 1,500 µm, and subfoveal MCT. The classification rates for the RF, SVM, and MLP algorithms were 98.6%, 96.8%, and 89%, respectively. Conclusion: Obesity has an effect on the choroidal thicknesses of children, particularly in the subfoveal region and the outer semi-circle at 1,500 µm from the optic disc head. Both the RF and SVM algorithms are effective and accurate at classifying obese and healthy children.


Subject(s)
Clinical Relevance , Pediatric Obesity , Humans , Child , Prospective Studies , Reproducibility of Results , Cross-Sectional Studies , Pediatric Obesity/diagnosis , Tomography, Optical Coherence/methods
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