ABSTRACT
BACKGROUND: Recent studies have shown a positive correlation between tumor-related immune response markers and the poor outcome in solid tumors. In this study, we aimed to investigate the neutrophil/lymphocyte ratio (NLR) in multiple myeloma. To the best of our knowledge, this would be the second report concerning this topic. METHODS: We retrospectively reviewed the data for 52 multiple myeloma patients. The patients were grouped using the baseline NLR as NLR ≤ 1.72 and NLR > 1.72 using receiver operating characteristic analysis to determine a cut off. We compared the two groups in terms of both the known prognostic factors of the myeloma and the overall survival (OS). RESULTS: Our study showed that NLR is associated with C-reactive protein and ß2 microglobulin (P = 0.02 and P = 0.001, respectively). The patients with NLR > 1.72 had significantly worse stages, performance status, and kidney functions. The whole group's OS was estimated as 35.1 months while the patients with lower NLR had better OS when compared with those with NLR > 1.72 (42.75 and 26.14 months, respectively, P: 0.04). CONCLUSION: Neutrophil/lymphocyte ratio, which is associated with stage, performance status, and kidney functions, can be used in daily practice as a predictor for survival in multiple myeloma. Simply adding NLR to the routine charts may enrich our data for larger studies.
Subject(s)
Lymphocytes/cytology , Multiple Myeloma/blood , Neutrophils/cytology , Adult , Aged , Aged, 80 and over , Female , Humans , Lymphocyte Count , Male , Middle Aged , Multiple Myeloma/mortality , Multiple Myeloma/pathology , PrognosisSubject(s)
Ear Canal/pathology , Lymphoma, T-Cell, Peripheral/diagnosis , Parotid Neoplasms/diagnosis , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Diagnostic Errors , Humans , Lymphoma, T-Cell, Peripheral/drug therapy , Lymphoma, T-Cell, Peripheral/pathology , Male , Middle Aged , Otitis Externa/diagnosis , Parotid Neoplasms/drug therapy , Parotid Neoplasms/pathology , Skin Ulcer/etiologyABSTRACT
Dental amalgam fillings are widely used all over the world. However, their mercury content can lead to various side effects and clinical problems. Acute or chronic mercury exposure can cause several side effects on the central nerve system, renal and hepatic functions, immune system, fetal development and it can play a role on exacerbation of neuromuscular diseases. In this case, we will present a patient with vacuolar myopathy whose symptoms were started and aggravated with her dental amalgam fillings.
