Do Hungarian multiple sclerosis care units fulfil international criteria?

A PATIENTS: Because of the past 3 decades' extensive research, several disease modifying therapies became available, thus a paradigm change is multiple sclerosis care was necessary. In 2018 a therapeutic guideline was created recommending that treatment of persons with multiple sclerosis should take place in specified care units where the entire spectrum of disease modifying therapies is available, patient monitoring is ensured, and therapy side effects are detected and treated promptly. In 2019 multiple sclerosis care unit criteria were developed, emphasizing personnel and instrumental requirements to provide most professional care. However, no survey was conducted assessing the real-world adaptation of these criteria. OBJECTIVE: To assess whether Hungarian care units fulfil international criteria. METHODS: A self-report questionnaire was assembled based on international guidelines and sent to Hungarian care units focusing on 3 main aspects: personnel and instrumental background, disease-modifying therapy use, number of people living with multiple sclerosis receiving care in care units. Data on number of persons with multiple sclerosis were compared to Hungarian prevalence estimates. Descriptive statistics were used to analyse data. RESULTS: Out of 27 respondent care units, 3 fulfilled minimum requirements and 7 fulfilled minimum and recommended requirements. The least prevalent neighbouring specialties were spasticity and pain specialist, and neuro-ophthalmologist and oto-neurologist. Only 15 centres used all available disease modifying therapies. A total number of 7213 people with multiple sclerosis received care in 27 respondent centres. Compared to prevalence estimates, 2500 persons with multiple sclerosis did not receive multiple sclerosis specific care in Hungary. CONCLUSION: Less than half of Hungarian care units provided sufficient care for people living with multiple sclerosis. Care units employing fewer neighbouring specialties, might have difficulties diagnosing and providing appropriate care for persons with multiple sclerosis, especially for people with progressive disease course, contributing to the reported low number of persons living with multiple sclerosis.

Utilization of acute vascular imaging and neurointervention for acute ischaemic stroke patients in 20 Hungarian stroke centers.

BACKGROUND AND PURPOSE: Acute mortality rate of stroke in Hungary is significantly higher than in Western Europe, which is likely to be partially attributable to suboptimal treatment. METHODS: We examined the use of acute vascular imaging and mechanical thrombectomy for acute ischaemic stroke patients. We collected data on 20 consecutive patients from Hungarian stroke centers before 31st August 2016. RESULTS: Out of the reported 410 patients, 166 (40.4%) underwent CT angiography and 44 (10.7%) had mechanical thrombectomy. CONCLUSION: Only about 1/3 of acute ischaemic stroke patients eligible for thrombectomy actually had it. The underlying reasons include long onset-to-door time, low utilization of acute vessel imaging and a limited neuro-intervention capacity needing improvement.

[Experience with intra-arterial thrombolysis in patients with acute stroke]. / Intraarterialis thrombolysissel szerzett tapasztalataink akut stroke kezelésében.

UNLABELLED: The authors report on their results with local intraarterial thrombolysis in four patients. PATIENTS: Three patients suffered from vertebrobasilar artery occlusion, and one from carotid-T occlusion. All were treated with local intraarterial thrombolysis by a joint team of neurologist, neuroanaesthesist and interventional neuroradiologist in the stroke-department of St. Stephen Municipal Hospital in collaboration with National Institute of Neurosurgery. Selection of patients suitable for successful intraarterial thrombolysis has to be done in the neurological department with help of ultrasound and neurological examination and CT scan. Patients were transferred to the therapeutic angiosuit and interventional treatment was initiated immediately upon establishing the diagnosis. At least one million units of urokinase was infused directly into the embolus in each case. RESULTS: Complete recanalisation was achieved in three of the four cases. That was associated with full recovery in two patients, in whom good collateral circulation and no signs of atherosclerotic lesions were found prior to treatment. Another patients has died despite of full recanalisation of the basilar artery. One patient survived after partial recanalisation of bilateral vertebral artery occlusion with mild residual tetraparesis. CONCLUSION: Local intraarterial thrombolysis is effective and is associated with good clinical outcome in properly selected patients. Careful and accurate ultrasound diagnostics of the site of occlusion plays a significant role in proper patient selection. Although difficult, acute intraarterial thrombolysis can be organized in a timely fashion even utilizing the required facilities in two different institutions, providing that all efforts is being made by each party for the fast diagnosis and treatment initiation.