ABSTRACT
This study compared the effect of systemic and local administration of alendronate on distraction osteogenesis in rabbit mandibles. Thirty New Zealand white rabbits were allocated to 3 groups: 10 rabbits for systemic alendronate; 9 for local alendronate; and 11 as controls. After a 5 day latency period, distraction was performed at a rate of 0.8mm/day for 9 days via a custom-made distractor. Animals were killed at the end of the consolidation period of 28 days. The distracted mandibles were harvested and evaluated by plain radiography, computed tomography (CT), dual energy X-ray absorptiometry (DEXA), and histomorphometry. Histologically, comparing the systemic and local alendronate groups, there were no statistically significant differences in the bone healing parameters, but each group showed a statistically superior effect over the control group (p<0.05). Quantitative CT evaluation showed a significant difference mean in the density of the regeneration between experimental and control groups. There was a significant increase in mean bone mineral density in the experimental groups compared with the control group. Histologic, CT, and DEXA analysis demonstrated that using systemic and local alendronate may be effective in accelerating new bone formation in the distraction gap in rabbit mandibles.
Subject(s)
Alendronate/administration & dosage , Bone Density Conservation Agents/administration & dosage , Mandible/drug effects , Osteogenesis, Distraction/methods , Absorptiometry, Photon/methods , Administration, Oral , Administration, Topical , Animals , Bone Density/drug effects , Bone Regeneration/drug effects , Drug Carriers , Gelatin Sponge, Absorbable/administration & dosage , Image Processing, Computer-Assisted/methods , Male , Mandible/pathology , Mandible/surgery , Osteogenesis/drug effects , Osteogenesis, Distraction/instrumentation , Rabbits , Tablets , Tomography, X-Ray Computed/methodsABSTRACT
Sinus floor elevation is increasingly being used with implant placement procedures. However, certain surgical difficulties can develop, such as sinus membrane perforation, bleeding, anatomic variations, or some pathologies of the maxillary sinus. Maxillary antral pseudocysts are one of the most common benign pathologies of the maxillary sinus. Although some investigators have described the presence of this pathology as a contraindication, recent reports have demonstrated that pseudocysts of the maxillary sinus are not a contraindication for sinus augmentation. In these reports, maxillary sinus augmentations related to antral pseudocyst experiences are presented.
Subject(s)
Alveolar Ridge Augmentation/methods , Cysts/pathology , Dental Implantation, Endosseous/methods , Maxillary Sinus/pathology , Oral Surgical Procedures, Preprosthetic/methods , Paranasal Sinus Diseases/pathology , Adult , Aged , Biopsy, Fine-Needle , Contraindications , Cysts/surgery , Humans , Male , Maxilla/surgery , Maxillary Sinus/surgery , Paranasal Sinus Diseases/surgery , Treatment OutcomeABSTRACT
OBJECTIVE: The objective of this study was to evaluate the effects of oil-based calcium hydroxide on mandibular lengthening during distraction osteogenesis. STUDY DESIGN: Twenty-four New Zealand white rabbits underwent unilateral mandibular osteotomy. The rabbits were divided into 4 groups containing 6 each: groups 1 and 3 were control groups and groups 2 and 4 were test groups. Oil-based calcium hydroxide suspension was applied to test groups' corticotomy gap after osteotomy during operation. No treatment was applied to the control groups. After 5 days' latency period, distraction was commenced at a rate of 0.8 mm/day for 10 days via custom-made distractor. Groups 1 and 2 were killed 14 days after distraction and groups 3 and 4 were killed 28 days after distraction. RESULTS: Quantitative computerized tomography evaluation did not demonstrate a difference mean the density and the area of the regeneration between groups 1 and 3, but there was a significant difference groups 2 and 4. Histomorphometric evaluation demonstrated that there was a significant difference between test and control groups in new bone volume formation during distraction osteogenesis. CONCLUSION: Application of oil-based calcium hydroxide paste during the osteotomy phase of distraction osteogenesis increased regeneration and new bone volume formation.
Subject(s)
Bone Substitutes/pharmacology , Calcium Hydroxide/pharmacology , Mandibular Advancement/methods , Osteogenesis, Distraction/methods , Osteogenesis/drug effects , Animals , Bone Regeneration/drug effects , Bony Callus/drug effects , RabbitsABSTRACT
AIM: The aim of this study was to evaluate the prevalence of signs and symptoms of temporomandibular disorders (TMD) in a population of 792 Turkish adults ranging in age from 15- to 72-years-old. METHODS AND MATERIALS: Subjects were examined objectively and subjectively for signs and symptoms of TMD through the distribution of frequency of the data obtained from a questionnaire and a physical examination using a similar methodology of previous studies. RESULTS: This study determined the prevalence of signs and symptoms of TMDs in subjects from male and female subgroups in a Turkish adult population. Both signs and symptoms of TMDs were generally more prevalent in females than in males. CONCLUSION: The prevalence of signs and symptoms were generally greater than in previous studies of other populations.
