[Interaction of melittin with ion channels of excitable membranes].

The effect of the neurotoxin melittin on the activation of ion channels of excitable membrane, the plasmalemma of Characeae algae cells, isolated membrane patches of neurons of mollusc L. stagnalis and Vero cells was studied by the method of intracellular perfusion and the patch-clamp technique in inside-out configuration. It was shown that melittin disturbs the conductivity of plasmalemma and modifieds Ca(2+)-channels of plant membrane. The leakage current that appears by the action of melittin can be restored by substituting calmodulin for melittin. Melittin modifies K(+)-channels of animal cell membrane by disrupting the phospholipid matrix and forms conductive structures in the membrane by interacting with channel proteins, which is evidenced by the appearance of additional ion channels.

[Characteristics of the diagnosis and treatment of severe forms of late pregnancy toxemia]. / Osobennosti diagnostiki i lecheniia tiazhelykh form pozdnykh toksikozov beremennykh.

Central and peripheral hemodynamics, organic (cerebral) blood flow, hemostasis system, clinical and biochemical values were comprehensively studied in 112 pregnant females with various severity of late gestoses (LG). As a result, there were developed diagnostic criteria both for the levels of severity and for its grave complication--the syndrome of disseminated intravascular blood coagulation. In 61 females the developed methods of efficient intensive care permitted to continue pregnancy up to spontaneous delivery.

[Metabolic changes in patients operated on in gynecologic diseases under ketamine anesthesia]. / Metabolicheskie izmeneniia u bol'nykh, operirovannykh po povodu ginekologicheskikh zabolevanii v usloviiakh anestesii ketaminom.

Changes in biochemical parameters have been studied in 58 patients during short-term gynecological surgery performed under ketamine or ketamine-diazepam anesthesia. Surgery under ketamine monoanesthesia was accompanied by a considerable activation of sympathoadrenal and hypophyseal-adrenal systems, which was regarded as inadequate anesthesia. A significant decrease in plasma histamine level has been observed.