[Lipid peroxidation and change in the lipid fraction of plasma in patients with hypertonic disease]. / Perekisnoe okislenie lipidov i izmenenie lipidnykh fraktsii plazmi krovi u bol'nykh gipertonicheskoi bolezn'iu.

Effect of lipid peroxidation on content and composition of blood plasma lipids was studied in 20 patients with hypertension within various periods after hypertonic crisis. Alterations in blood plasma lipid spectrum were shown to be related to initiation of lipid peroxidation in cell membranes. Dynamics of lipid peroxidation in individual blood plasma lipid fractions appears to reflect the adaptation under conditions of the pathological state of the organism.

[The function of membrane Ca-ATPases and nonenzymatic peroxidation of membrane lipids in patients with hypertension]. / Funktsiia membrannykh Ca-ATFaz i nefermentativnoe perekisnoe okislenie lipidov kletochnykh membran u bol'nykh gipertonicheskoi bolezn'iu.

Alterations in activity of membrane-bound Ca2(+)-ATPases were shown to depend on the rate of lipid peroxidation in cell membranes of patients with hypertension during the period of crisis. On the basis from these results antioxidants and Ca2(+)-antagonistic drugs could be used for treatment of hypertensive crisis. Monitoring of the disease is possible by means of estimation of the membrane-bound Ca2(+)-ATPases activity.