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1.
Postepy Dermatol Alergol ; 30(5): 320-3, 2013 Oct.
Article in English | MEDLINE | ID: mdl-24353494

ABSTRACT

The Schimmelpenning-Feuerstein-Mims (SFM) syndrome is a rare phakomatosis which comprises a nevus sebaceous of Jadassohn, seizures and developmental delay associated with a wide spectrum of extracutaneous abnormalities including neurological, skeletal, ocular, cardiovascular and urogenital defects. We are presenting a case of an 18-year-old patient with systemic features of the SFM syndrome and an extensive linear nevus sebaceous partially removed with a carbon dioxide (CO2) laser. The treatment options of skin lesions in patients with SFM are discussed.

2.
Ann Acad Med Stetin ; 59(2): 12-7, 2013.
Article in Polish | MEDLINE | ID: mdl-25026745

ABSTRACT

INTRODUCTION: Psoriasis is a chronic inflammatory dermatosis leading to the development of systemic inflammatory reaction. Previous data indicated the coexistence of psoriasis and the occurrence of metabolic disorders, with the common background of both processes determined by a chronic inflammation. The coexisting disorders, including type 2 diabetes, hypertension, heart ischemic disease, dislipidemia and obesity may have an important impact on intensity of psoriasis activity. MATERIAL AND METHODS: The analysis comprised of 82 randomly matched patients with various clinical forms of psoriasis, aged 17 to 81 years. In patients PASI and BSA indexes, BMI value and laboratory parameters of metabolic status (glucose and ureic acid levels, lipid fractions and CRP level in the serum) were evaluated. RESULTS: An average age in examined group was 54,3 years, an average time of presence of psoriasis symptoms was approximately 20 years. An average PASI value was 21,4; an average BSA value was 39.7%. The coexistence of type 2 diabetes was found in 14.6% of patients, hypertension in 42.7% and heart ischemic disease in 17%. Particularly large group of examined patients comprised persons with overweight (34.1%) and obesity (30.5%). Positive correlation between BSA and body weight, BSA and BMI value, BSA and abdominal circumference as well as positive correlation between PASI and body weight, PASI and BMI value, PASI and abdominal circumference were observed. Abnormal serum glucose levels were observed in 19.5% persons, ureic acid level in 2.9%, total cholesterol in 37.8% LDL cholesterol in 48.8%, and HDL cholesterol in 46.3%. CRP level was elevated in 43.9% patients. Positive correlation between BSA and ureic acid level, as well as PASI and ureic acid level was estimated. No correlation between PASI and the other laboratory parameters was found. CONCLUSIONS: The occurrence of metabolic syndrome is more common in patients with psoriasis in comparison to the general population. The extent and severity of psoriatic lesions correlate with high body weight, BMI and the level of ureic acid.


Subject(s)
Metabolic Syndrome/blood , Metabolic Syndrome/epidemiology , Psoriasis/blood , Psoriasis/epidemiology , Adolescent , Adult , Aged , Aged, 80 and over , C-Reactive Protein/analysis , Cholesterol/blood , Cholesterol, HDL/blood , Cholesterol, LDL/blood , Comorbidity , Female , Humans , Male , Metabolic Syndrome/diagnosis , Middle Aged , Obesity/epidemiology , Overweight/epidemiology , Psoriasis/diagnosis , Risk Factors , Uric Acid/blood , Young Adult
3.
Ann Acad Med Stetin ; 59(2): 67-70, 2013.
Article in Polish | MEDLINE | ID: mdl-25026753

ABSTRACT

The case of a 62-year-old female patient diagnosed with an extremely rare clinical variant of pemphigoid--nodular pemphigoid, imitating prurigo nodularis, is presented in the paper. In connection with the existence of the typical prurigo nodularis-like appearance in the patient, the diagnosis was maintained for several months. However, because of no response to the treatment and the remarkably chronic course of the disease, the patient was admitted to the Department in order to extend the diagnostics and verify the previous diagnosis. The direct and indirect immunofluorescence examinations performed on the patient enabled the final diagnosis of a rare variant of pemphigoid without typical blisters, and effective treatment was carried out.


Subject(s)
Pemphigoid, Bullous/diagnosis , Pemphigoid, Bullous/pathology , Cyclophosphamide/therapeutic use , Female , Humans , Middle Aged , Pemphigoid, Bullous/drug therapy
4.
Ann Acad Med Stetin ; 57(3): 23-7, 2011.
Article in Polish | MEDLINE | ID: mdl-23383544

ABSTRACT

Vitiligo is an idiopathic chronic skin disease that is notable for depigmented macules forming by destruction of melanocytes mediated by cells of the immune system. Vitiligo occurs in 1-2% of the population irrespective of race and without predilection to gender or age. The dynamics and extent of the disease vary widely, ranging from stable cases with isolated minor foci to states showing rapid progression and occupying large areas of the skin. For many patients, the disease represents a serious cosmetic defect which limits their activities in various spheres of life. There are many noninvasive methods of treatment but none of them offers a guarantee of complete therapeutic success. PUVA- and UVB-therapy are recognized as the most effective and most commonly used methods. The management of vitiligo should also include education, cosmetic correction options, and psychotherapy in some cases.


Subject(s)
Esthetics , Vitiligo/therapy , Disease Progression , Humans , Hypopigmentation/etiology , Hypopigmentation/prevention & control , Hypopigmentation/psychology , PUVA Therapy , Phototherapy , Psychotherapy , Ultraviolet Therapy , Vitiligo/complications
5.
Ann Acad Med Stetin ; 57(1): 38-44, 2011.
Article in Polish | MEDLINE | ID: mdl-22593989

ABSTRACT

Antimalarial drugs--chloroquine, hydroxychloroquine and quinacrine, initially devised for the treatment of malaria, have been used in the therapy of diverse skin diseases, including lupus erythematosus, dermatomyositis, porphyria cutanea tarda, and sarcoidosis. The mechanism of action of these drugs involves stabilization of lysosomal enzymes, inhibition of antigen-presenting cells and T lymphocyte stimulation, blocking of the pro-inflammatory cytokine cascade and endosomal toll-like receptor signaling. The understanding of potential mechanisms of action of antimalarials may extend their use to new areas in dermatology. This work describes the pharmacologic properties of antimalarial drugs and indications for their use in clinical practice. Moreover, the most important limitations of therapy with antimalarials and their adverse side effects are discussed.


Subject(s)
Antimalarials/pharmacology , Antimalarials/therapeutic use , Skin Diseases/drug therapy , Antigen-Presenting Cells/drug effects , Antimalarials/adverse effects , Dermatomyositis/drug therapy , Humans , Lupus Erythematosus, Systemic/drug therapy , Porphyria Cutanea Tarda/drug therapy , Sarcoidosis/drug therapy
6.
Ann Acad Med Stetin ; 54(2): 52-8, 2008.
Article in Polish | MEDLINE | ID: mdl-19374232

ABSTRACT

INTRODUCTION: Every adverse and undesirable event observed after administration of the therapeutic dose of the drug is defined as adverse drug reaction. The aim of the study was to evaluate the incidence frequency of cutaneous adverse drug reactions, to define the drugs inducing such reactions and to define the type of the most frequently found lesions in patients admitted to Department of Dermatology and Venereology of Pomeranian Medical University in Szczecin (PAM) in 1996-2006. MATERIAL AND METHODS: A retrospective analysis of medical files of the patients, who were hospitalized in the Department of Dermatology and Venereology of PAM in Szczecin in 1996-2006, was carried out. Due to cutaneous adverse drug reactions, 386 patients were hospitalized. They made 4.25% of all admitted to our Department. RESULTS: These reactions were found more frequently in females (65.5%) than in males (34.5%). Non-steroidal anti-inflammatory drugs induced adverse events most frequently (37.6%), followed by aminopenicillin antibiotics, particularly amoxycillin-containing agents, responsible for 25.8% of these reactions. Other antibiotics were responsible for undesirable events less frequently--9.6%. Macular and maculopapular rashes were the most frequently observed adverse cutaneous drug reactions (42.0% of the cases), followed by acute urticaria and Quincke's oedema (39.1% of all reactions), whereas contact dermatitis after topical drugs was found in 8.0% of the cases. CONCLUSIONS: Cutaneous adverse drug reactions were mainly induced by non-steroidal anti-inflammatory drugs and aminopenicillin antibiotics. The most frequent forms of cutaneous adverse drug reactions were maculopapular rashes, acute urticaria and Quincke's oedema.


Subject(s)
Drug Eruptions/epidemiology , Administration, Topical , Adult , Age Distribution , Aged , Aged, 80 and over , Anti-Bacterial Agents/administration & dosage , Anti-Bacterial Agents/adverse effects , Anti-Inflammatory Agents, Non-Steroidal/adverse effects , Anticonvulsants/adverse effects , Cardiovascular Agents/adverse effects , Drug Eruptions/classification , Drug Eruptions/etiology , Female , Humans , Male , Middle Aged , Poland/epidemiology , Retrospective Studies , Sex Distribution
7.
Ann Acad Med Stetin ; 54(3): 54-7, 2008.
Article in Polish | MEDLINE | ID: mdl-19839512

ABSTRACT

The paper presents current opinions on aetiopathogenesis of dry skin including its occurrence in the course of certain dermatological disorders. A meaning of natural moisturizing factor, lipid barrier as well as epidermal differentiation processes in the maintenance of the proper skin moisturization is described. The importance of topical treatment is emphasized. Moreover, a survey of moisturizing factors applied in dry skin care is included.


Subject(s)
Cosmetics/administration & dosage , Skin Care/methods , Skin Diseases/therapy , Administration, Topical , Cell Differentiation , Epidermis/pathology , Humans , Skin Diseases/pathology
8.
Pol Arch Med Wewn ; 107(1): 53-8, 2002 Jan.
Article in Polish | MEDLINE | ID: mdl-12046344

ABSTRACT

The case of a 32-year old female patient with primary hypothyroidism suffering from severe myxoedema as a consequence of denying thyroxin taking is presented. Severe expression of pathological changes in circular-respiratory system and uncommon skin changes are discussed.


Subject(s)
Hypothyroidism/drug therapy , Myxedema/etiology , Thyroxine/administration & dosage , Treatment Refusal , Adult , Female , Humans , Hypothyroidism/complications
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