ABSTRACT
In sarcoidosis, the cytomorphologic pattern of aspirates shows a predominant progressive inflammation without exudative reaction and caseous necrosis, round granulomas with signs of polymorphism with the presence of mononuclear elements, giant cells by the "foreign body" type and development of pronounced fibrosis.
Subject(s)
Lung Diseases/pathology , Lung/pathology , Lymph Nodes/pathology , Lymphatic Diseases/pathology , Sarcoidosis/pathology , Adult , Aged , Biopsy, Needle , Female , Humans , Male , Middle AgedABSTRACT
A detailed complex examination was carried out of patients with sarcoidosis in ambulatory conditions using modern clinicoroentgenological, bronchological, immunological, morphological methods. Considering the tendency of the disease to spontaneous regression the outpatient screening proved efficient in the diagnosis of 250 patients. The employed complex allowed to reduce the time of diagnosis and to choose optimal methods of treatment.
Subject(s)
Ambulatory Care , Lung Diseases/diagnosis , Sarcoidosis/diagnosis , Skin Diseases/diagnosis , Diagnosis, Differential , Humans , Methods , Remission, SpontaneousABSTRACT
Sarcoidosis ran a favourable course in 166 out of 179 patients. The active phase of sarcoidosis was characterized by dysproteinemia, high content of histamine, STH and beta-lipoproteins together with a decrease of HPI and total protein. More remarkable shifts were observed in patients afflicted with sarcoidosis of the intrathoracic lymph nodes and of the lungs. In the phase of regression, there was a unidirectional change in the majority of the parameters, which correlated with the process liability to the reverse development. It may be recommended that the content of histamine, HPI and beta-lipoproteins should be measured along with other parameters to estimate the process activity in patients with respiratory sarcoidosis.
