ABSTRACT
OBJECTIVE: The aim: In this work we developed a method of continuous recrystallization to meet industrial requirements. PATIENTS AND METHODS: Materials and methods: Continuous recrystallization method was investigated using porous ceramic filter for water purification with pour size less than 1 µm, that ensures high mixing rate of ethanol and water. RESULTS: Results and conclusions: The results of experiments using crystallization through ceramic filter, gives superior products in particle size, and produced needle shaped ceftriaxone crystals form, that showed significant improvement in dissolution time and obtained ceftriaxone sodium powder to be reconstituted in injectable formula that give clear solution without insoluble microparticles.
