1.
Eksp Klin Farmakol
; 73(6): 33-5, 2010 Jun.
Article
in Russian
| MEDLINE
| ID: mdl-20726349
ABSTRACT
The toxicity of new gamma-carboline derivative [ethyl 3-(8-fluoro-2-methyl-2,3,4,5-tetrahydro-1H-gamma-carbolin-5-yl)-propionate dihydrochloride, CD-008-040] has been studied.
Subject(s)
Anti-Allergic Agents/adverse effects , Anti-Allergic Agents/pharmacology , Carbolines/adverse effects , Carbolines/pharmacology , Animals , Dose-Response Relationship, Drug , Drug Evaluation, Preclinical , Humans , Male , Mice
2.
Eksp Klin Farmakol
; 73(3): 28-30, 2010 Mar.
Article
in Russian
| MEDLINE
| ID: mdl-20408427
ABSTRACT
The influence of ethyl-3-(8-fluoro-2-methyl-2,3,4,5-tetrahydro-1H-gamma-carboline-5-yl)propionate dihydrochloride belonging to the class of gamma-carbolines on the allergic reactions (inflammation and systemic anaphylaxis) has been studied on laboratory animals. It was established that the given substance administered in a dose of 5 - 20 mg/kg exhibits a pronounced antiallergic action. Unlike many other antihistamine drugs, this gamma-carboline derivative probably does not produce sedative effect.
