Lacosamide Intoxication-induced Wide QRS Tachycardia Successfully Treated with Veno-arterial Extracorporeal Membrane Oxygenation.

Lacosamide is an antiepileptic drug that acts on voltage-gated sodium channels and was approved as an antiepileptic by the Food and Drug Administration in 2008. Although the efficacy and safety of lacosamide have been established in many previous trials, some case reports have shown that it may lead to cardiovascular side effects, especially in patients with electrical conduction system disorders. We herein report a case of life-threatening cardiac arrhythmia caused by lacosamide intoxication that was successfully treated with veno-arterial extracorporeal membrane oxygenation.

Transcatheter Arterial Embolization of a Gluteal Pseudoaneurysm Due to Ground-Level Fall in an Elderly Woman Taking Apixaban.

A 90-year-old woman prescribed with apixaban was admitted to a hospital after a ground-level fall. She was transferred to our hospital for advanced evaluation and treatment. Contrast-enhanced computed tomography showed a pseudoaneurysm inside the right gluteus maximus muscle. Angiography revealed an aneurysm of the peripheral branch of the inferior gluteal artery and multiple slight pseudoaneurysms of the peripheral branch of the internal iliac artery. We performed transcatheter arterial embolization using a gelatin sponge. After embolization, the hemoglobin stabilized. She was transferred to another hospital for rehabilitation. The use of direct oral anticoagulants in the elderly can lead to significant hemorrhage with minimal trauma. Transcatheter arterial embolization is a minimally invasive and safe procedure for such cases of trauma.

[Anesthetic Management of Open Reduction for a Femoral Neck Fracture in a Patient Complicated with Fat Embolism Syndrome.]

We experienced anesthetic management of open reduction for a femoral neck fracture in a patient com- plicated with fat embolism syndrome. An 83-year-old woman with a femoral neck fracture was admitted to our hospital after suffering an injury. She developed hypoxemia on admission. Chest X-ray showed a decrease in permeability of the right lung and chest CT scan showed ground glass opacities of the right lung. A blood test showed anemia, thrombocytopenia, and elevation of C-reactive protein. She was diagnosed with fat embolism syndrome using the classification of Tsuruta. Oxygen was administered. C-reactive protein decreased gradually after hospitalization. Echocardiog- raphy showed normal left ventricular function without pulmonary hypertension. She was scheduled for open reduction for the femoral neck fractu-e with artificial grit insertion under general anesthesia 6 days after hospitalization. Her operation was performed with- out exacerbation of the fat embolism syndrome. She was extubated in the operating room, and was dis- charged from the recovery room without any conpli- cations. After surgery, chest X-ray showed further improvement and she was transferred to a rehabilita- tion hospital on the 27th hospital day.