Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Type of study
Language
Publication year range
1.
Clin Exp Immunol ; 170(2): 202-11, 2012 Nov.
Article in English | MEDLINE | ID: mdl-23039891

ABSTRACT

Common variable immunodeficiency disorders (CVID) are a group of heterogeneous conditions that have in common primary failure of B cell function, although numerous T cell abnormalities have been described, including reduced proliferative response and reduced regulatory T cells. This study compared the T cell phenotype of CVID patients subdivided into clinical phenotypes as well as patients with partial antibody deficiencies [immunoglobulin (Ig)G subclass deficiency and selective IgA deficiency], X-linked agammaglobulinaemia (XLA) and healthy and disease controls. Absolute numbers of T cell subpopulations were measured by four-colour flow cytometry: naive T cells, central and effector memory and terminally differentiated (TEM) T cells, using CD45RA and CCR7 expression. Early, intermediate and late differentiation status of T cells was measured by CD27/CD28 expression. Putative follicular T cells, recent thymic emigrants and regulatory T cells were also assessed. Significant reduction in naive CD4 T cells, with reduced total CD4 and recent thymic emigrant numbers, was observed in CVID patients, most pronounced in those with autoimmune cytopenias or polyclonal lymphoproliferation. These findings suggest a lack of replenishment by new thymically derived cells. CD8 naive T cells were reduced in CVID patients, most significantly in the autoimmune cytopenia subgroup. There was a reduction in early differentiated CD4 and CD8 T cells and increased CD8 TEM in the CVID patients, particularly autoimmune cytopenia and polyclonal lymphoproliferation subgroups, suggesting a more activated T cell phenotype, due perhaps to an antigen-driven process. XLA patients had significantly reduced putative follicular T cells, which may depend on B cells for survival, while no significant alterations were observed in the T cells of those with IgG subclass deficiency or selective IgA deficiency.


Subject(s)
Common Variable Immunodeficiency/immunology , T-Lymphocyte Subsets/immunology , Adolescent , Adult , Agammaglobulinemia/immunology , Aged , Aged, 80 and over , Antigens, CD/immunology , B-Lymphocyte Subsets/immunology , Cell Differentiation/immunology , Child , Child, Preschool , Female , Genetic Diseases, X-Linked/immunology , Humans , Immunoglobulin A/immunology , Immunoglobulin G/immunology , Infant , Lymphocyte Activation/immunology , Male , Middle Aged , Phenotype , Receptors, CCR7/immunology , Young Adult
SELECTION OF CITATIONS
SEARCH DETAIL
...