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Gig Sanit ; (10): 28-30, 1990 Oct.
Article in Russian | MEDLINE | ID: mdl-2074021

ABSTRACT

Fungicide tecto (thiabendazol) is a low-toxic compound, produces a weak skin-resorptive and local irritating effect. Cumulation coefficient is 3.96. Threshold and subthreshold doses for tecto were determined as a result of 12-months chronic experiment on white rats--3.7 and 0.37 mg/kg, respectively. The allowable 24-hours dose for human exposure to the chemical is 0.6 mg. The threshold tecto concentration according to the effect on the general sanitary regimen of water reservoirs appeared to be 1 mg/l. According to the limiting toxicological index 0.05 mg/l was recommended as tecto MAC for the water of reservoirs.


Subject(s)
Fungicides, Industrial/toxicity , Thiabendazole/toxicity , Water Pollutants, Chemical/toxicity , Animals , Dose-Response Relationship, Drug , Female , Fungicides, Industrial/pharmacokinetics , Fungicides, Industrial/pharmacology , Lethal Dose 50 , Male , Maximum Allowable Concentration , Rabbits , Rats , Thiabendazole/pharmacokinetics , Thiabendazole/pharmacology , Water Pollutants, Chemical/pharmacokinetics , Water Pollutants, Chemical/pharmacology
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