1.
Vopr Med Khim
; 37(2): 44-6, 1991.
Article
in Russian
| MEDLINE
| ID: mdl-1897193
ABSTRACT
Effect af antiischemic drug mildronate 3-(2,2,2-trimethylhydrazinium) propionate on oxidation of sodium octanoate and L-palmitoyl carnitine was studied in liver mitochondria of intact rats using polarographic procedure. After 10 days of administration of mildronate at a dose of 200 mg/kg per os oxidation of sodium octanoate was stimulated in liver mitochondria while the rate of L-palmitoyl carnitine oxidation was unaltered. The data obtained suggest that mildronate stimulated the carnitine-independent fatty acid oxidation which appears to occur as a compensation for inhibition of the carnitine-dependent oxidation by the drug.
Subject(s)
Carnitine/metabolism , Fatty Acids/metabolism , Methylhydrazines/pharmacology , Mitochondria, Liver/drug effects , Animals , Male , Mitochondria, Liver/metabolism , Oxidation-Reduction , Rats
2.
Vopr Onkol
; 36(3): 269-76, 1990.
Article
in Russian
| MEDLINE
| ID: mdl-2184579