Is having a moderate or low history, electrocardiogram, age, risk factors, troponin risk score a handicap for long-term mortality?

OBJECTIVE: History, electrocardiogram, age, risk factors, troponin risk score and troponin level follow-up are used to safely discharge low-risk patients with suspected non-ST elevation acute coronary syndrome from the emergency department for a 1-month period. We aimed to comprehensively investigate the 6-month mortality of patients with the history, electrocardiogram, age, risk factors, troponin risk score. METHODS: A total of 949 non-ST elevation acute coronary syndrome patients admitted to the emergency department from 01.01.2019 to 01.10.2019 were included in this retrospective study. History, electrocardiogram, age, risk factors, troponin scores of all patients were calculated by two emergency clinicians and a cardiologist. We compared the 6-month mortality of the groups. RESULTS: The mean age of the patients was 67.9 (56.4-79) years; 57.3% were male and 42.7% were female. Six-month mortality was significantly lower in the high-risk history, electrocardiogram, age, risk factors, troponin score group than in the low- and moderate-risk groups: 11/80 (12.1%), 58/206 (22%), and 150/444 (25.3%), respectively (p=0.019). CONCLUSION: Patients with high history, electrocardiogram, age, risk factors, troponin risk scores are generally treated with coronary angioplasty as soon as possible. We found that the mortality rate of this group of patients was lower in the long term compared with others. Efforts are also needed to reduce the mortality of moderate and low-risk patients. Further studies are needed on the factors affecting the 6-month mortality of moderate and low-risk acute coronary syndrome patients.

Developing and Validating a New Model to Predict In-Hospital Mortality in Patients with Acute Myocardial Infarction.

OBJECTIVE: To derive and validate a regression model that can successfully and robustly predict in-hospital mortality of patients who underwent percutaneous coronary intervention (PCI) after admission to the Department of Emergency Medicine (ED) with acute myocardial infarction (AMI). STUDY DESIGN: Cohort study. Place and Duration of the Study: ED of University of Health Sciences, Sancaktepe Training and Research Hospital, that worked as a PCI centre between January and March 2022. METHODOLOGY: Patients older than 18 years of age, diagnosed with acute ST elevation myocardial infarction (STEMI) or non-STEMI (NSTEMI) in the ED, and consequently underwent PCI were included. Patients with missing information of the outcome were excluded. For the regression model, backward stepwise logistic regression was utilised. The non-random split-sample development and validation method was used for the internal and external validation of the model. Ejection fraction, diastolic blood pressure, haemoglobin A1c, and haemoglobin were selected as the predictors. RESULTS: A total of 279 patients were included in the analysis. The area under the curve (AUC) of the final model in the derivation cohort was 0.982 (95% CI = 0.956-1.0). The sensitivity was 92.3% (95% CI = 64-99.8) and the specificity was 96.2% (95% CI = 92.3-98.4). The AUC of the final model in the validation cohort was 0.956 (95% CI = 0.904-1.0). The sensitivity was 80% (95% CI = 28.3-99.5) and the specificity was 92.3% (95% CI = 84-97.1). CONCLUSION: The suggested model generated results that can be utilised as a screening tool for predicting in-hospital mortality in patients diagnosed with STEMI or NSTEMI who are admitted to PCI in emergency medicine settings. Nonetheless, it is essential to validate the model in different populations. KEY WORDS: Percutaneous coronary intervention, Mortality, In-hospital mortality, Prediction model, Logistic regression.

[Investigation of Group A Rotavirus G10, G12 Genotypes Emerging in Patients with Acute Gastroenteritis in a Tertiary Care Hospital]. / Hastanemize Basvuran Akut Gastroenteritli Hastalarda Yeni Görülmeye Baslayan A Grubu Rotavirüs G10, G12 Genotiplerinin Arastirilmasi.

Rotaviruses are the most common cause of viral gastroenteritis with the highest mortality and morbidity rates in children aged 0-5 years. The aim of this study was to determine the frequency of rotavirus infection in patients whose stool samples were sent to microbiology laboratory to investigate the etiology of diarrhea, to investigate the rotavirus genotypes that are common in our region and G10, G12 genotypes that have recently become common in the world. Fecal samples of 476 patients aged between 0-92 years who applied between November 2016 and February 2018 were studied via immunochromatographic rapid test and enzyme-linked immunosorbent assay (ELISA) methods. ELISA positive samples were studied by nested reverse transcriptase chain reaction (RT-PCR) and genotyped by agarose gel electrophoresis. Rotavirus was found positive in 18.3% and 17% of stool samples by immunochromatographic test and ELISA, respectively. All ELISA positive samples were also detected as positive by RT-PCR. 18.5% of female patients and 15.7% of male patients were found to be positive and rotavirus positivity was not statistically significant between genders. The frequency of rotavirus in different age groups was 23.5% (6-12 years), 17.3% (13-24 months) and 16% (25-36 months). It was determined that rotavirus cases were most common in the spring. G1, G2, G3, G4, G9, G10, and G12 were detected in 37%, 7.4%, 16.1%, 6.2%, 9.9%, 2.5%, 26% of the samples, respectively. G12 was the most common genotype after G1. The most common G and P genotype combination was G1P[8] (17.2%). This was followed by G12P[8] (11.11%) and G3P[8] (11.11%). P[8] (53%) was found to be the dominant P genotype. In this study, it was observed that rotavirus, which is the cause of childhood diarrhea, can also be encountered in advanced ages and even new genotypes that infect humans worldwide may also be the causative agents. Therefore, we concluded that it is important to investigate new genotypes such as G10 and G12 in molecular epidemiological studies.