ABSTRACT
One hundred twenty strains of adenovirus types 1, 2, 5, and 6 (subgenus C), isolated at various times and places, were tested by neutralization and hemagglutination inhibition with two antisera of each type. Except for one type 5 strain they reacted largely type-specifically in both tests and neither qualitative nor quantitative differences were observed. Serologically intermediate strains were not found. The antigenic homogeneity is in contrast to the heterogeneity of the genomes of subgenus C adenoviruses.
Subject(s)
Adenoviruses, Human/classification , Antigens, Viral/analysis , Epitopes/analysis , Adenoviruses, Human/analysis , Adenoviruses, Human/genetics , Adenoviruses, Human/immunology , Adenoviruses, Human/isolation & purification , Hemagglutination Tests/methods , Humans , Neutralization Tests/methods , SerotypingABSTRACT
A group of novel 4-substituted phenylacetic acids were prepared and coupled with several 7-amino-delta-3-cephems to afford a family of parenterally active cephalosporins. A compound designated 13I had the broadest spectrum of activity and the highest potency of the group against both Gram-positive and Gram-negative bacteria. The activity of 13I included high potency against penicillinase-producing staphylococci and activity against anaerobes, including Bacteroides fragilis.
