[The relation of arterial pressure and the rate of Na-Li countertransport in a representative subsample of the population of Moscow residents]. / Zavisimost' mezhdu arterial'nym davleniem i skorost'iu Na-Li-protivotransporta v reprezentativnoi podvyborke iz populiatsii zhitelei Moskvy.

A study was made of the relationship between Na-Li countertransport and arterial blood pressure in 95 persons selected at random from the representative sample (n = 1716) of the population of one of the districts of Moscow. Of these, 34 persons turned out to be normotensive, 15 had borderline hypertension, 44 stable essential hypertension, and 2 persons presented with secondary hypertension. A positive correlation was found between countertransport and age and weight, determining 20.4% of interindividual variability of countertransport values. The mean value of countertransport in the hypertension group appeared much higher than in the normotensive group, both without and with regard to the correlating parameters. Repeated examinations demonstrated that the countertransport value in each person remained unchanged for two years. A nonlinear correlation was discovered between countertransport and arterial blood pressure. The rate of countertransport is not related to arterial blood pressure (low and high values). A dramatic change in the countertransport values occurred within a narrow borderline range of arterial blood pressure.

[Na-Li countertransport and the diagnosis of hypertension and combined hypertension and renal artery stenosis]. / Na-Li-protivotransport i diagnostika gipertonicheskoi bolezni, sochetaniia gipertonicheskoi bolezni i stenozov pochechnykh arterii.

The rate of Na-Li countertransport was studied in inpatients with essential hypertension (n = 59), chronic diffuse glomerulonephritis (n = 30), chronic pyelonephritis (n = 26), renovascular hypertension (n = 15) and in those with associated renovascular hypertension and essential hypertension (n = 4). Multiple regression analysis has demonstrated that age, body weight and blood plasma lipids do not make any significant contribution to dispersion of the counter transport rate. The mean rate of countertransport in patients with essential hypertension turned out much higher than that in patients with secondary hypertensions. Repeated examinations have shown that in every man, the countertransport rate remains unchanged for 1.5 yr. It is not affected either by hypotensive therapy or surgical treatment. In inpatients with secondary hypertension and low rates of countertransport, high arterial pressure (AP) drops after surgical treatment of the kidneys, renal vessels or adrenals. Surgical treatment of patients with secondary hypertension and high rates of countertransport does not lead to any material decrease of AP. It is assumed that the rate of Na-Li countertransport can be used for diagnosing associated secondary hypertensions and essential hypertension and prediction of AP lowering after surgical treatment.

[Study of the relation of various genetic and pathophysiologic factors participating in the regulation of blood pressure in patients with hypertension]. / Izuchenie vzaimosviazi mezhdu nekotorymi geneticheskimi i patofiziologicheskimi faktorami, uchastvuiushchimi v reguliatsii arterial'nogo davleniia u bol'nykh gipertonicheskoi bolezn'iu.

A study of 35 patients with uncomplicated essential hypertension (EH) (labile hypertension, stages IB-IIA or stable hypertension, stage IIB) demonstrated a higher rate of Na+-Li+ countertransport in patients with hypertensive hereditary predisposition to EH (group 1), as compared to those with unaggravated heredity (group 2). A suppression of plasma renin activity (53%), and a higher rate of hyperlipoproteinemia (55%) were observed in group 1, as opposed to group 2 where Na+-Li+ countertransport was lower, plasma renin activity was normal, and hyperlipoproteinemia occurred in 33%. There was a direct correlation between Na+-Li+ countertransport and renin-angiotensin-aldosterone components in group 2. A conclusion is made that aggravated heredity, RAAS components and hyperlipoproteinemia should be taken into account in the assessment of Na+-Li+ countertransport in hypertensive patients.

[Sodium and lithium transport and steroid hormones of the adrenal glands]. / Transport natriia i litiia i steroidnye gormony nadpochechnikov.

Erythrocyte Na-Li countertransport was determined in 42 patients with essential hypertension (EH), 36 patients with hypertensive chronic diffuse glomerulonephritis, 47 patients with chronic pyelonephritis, 19 patients with renovascular hypertension and 9 patients with primary aldosteronism (PA). None of PA patients was treated with verospiron. Individual assessment of Na-Li exchange was made in 15 patients with nonspecific aorto-arteritis (NAA), untreated by steroid hormones, and in 2 glucocorticoid-treated NAA patients. Na-Li exchange parameters were compared before and after surgery in 7 patients with arterial hypertension (AH). Mean rate of Na-Li countertransport was nearly twice as high in EH patients as compared to the respective rate in patients with renal AH, whereas the difference in mean countertransport rates was not significant between EH and PA patients. Increased Na-Li exchange rate went down to normal values in a PA patient, while postoperative hydrocortizone treatment increased this rate in a patient with pheochromocytoma. In the remaining patients with symptomatic hypertensions (renovascular hypertension, pyelonephritic granular kidney, aortic coarctation, pheochromocytoma), Na-Li exchange remained unchanged after surgery. The rate of Na-Li exchange was increased in prednisolone-treated NAA patients, as compared to NAA patients receiving no glucocorticoids. The level of Na-Li exchange was stable over 9-18 months in AH patients with normal plasma aldosterone levels. No effects of obsidan, corinfar, clophelin, furosemide, hypothiazide and triampur on Na-Li exchange were identified.

[Clinical importance of determining Na-Li countertransport in patients with arterial hypertension]. / Klinicheskoe znachenie opredeleniia Na--Li-protivotransporta u bol'nykh arterial'nymi gipertoniiami.

Erythrocyte Na-Li countertransport was assessed in 99 patients with various arterial hypertensions. Mean Na-Li countertransport rate was 476 +/- 43 mumol/l 1 cells/hour in essential hypertension, or nearly twice as high as mean rates for hypertensive chronic diffuse glomerulonephritis, chronic pyelonephritis, renovascular hypertension and nonspecific aortoarteritis, primarily affecting extracranial arteries. In 2 patients, operated on for renal arterial stenosis, Na-Li countertransport was high and the operation had no hypotensive effect, suggesting that renal arterial stenosis was combined with essential hypertension. In 1 patient, the original diagnosis of chronic diffuse glomerulonephritis and aldosteronoma was not confirmed at surgery and renal biopsy, and the diagnosis of essential hypertension was made instead.

[Clinical value of determining Na-Li countertransport in the diagnosis of arterial hypertension associated with minor urinary syndrome]. / Klinicheskoe znachenie opredeleniia Na-Li-protivotransporta dlia diagnostiki arterial'nykh gipertonii, protekaiushchikh s malym mochevym sindromom.

Na-Li-countertransport was determined in 117 patients aged 16-17. The main groups included 22 patients with essential hypertension accompanied by minor urinary syndrome; 12 patients with hypertensive form of chronic diffuse glomerulonephritis; and 21 patients with chronic pyelonephritis either with or without urinary syndrome who exhibited no severe alterations in function, shape and structure of kidneys according to instrumental findings. 23 patients with chronic diffuse glomerulonephritis and 24 patients with chronic pyelonephritis reliably diagnosed by instrumental methods as well as patients with essential hypertension without urinary syndrome were included into groups of comparison. Patients with essential hypertension from both groups had individual Na-Li-countertransport values over 300 mumol/l RBC/hr; nevertheless, mean values of countertransport as well as systolic and diastolic BP levels were higher in the main group. Individual Na-Li-countertransport rates in patients with parenchymatous renal diseases did not exceed in overwhelming majority of cases 300 mumol/l RBC/hr. Main groups and groups of comparison did not differ in mean values of countertransport.

[Comparative pharmacological characteristics of peptides of the atrial natriuretic factor family]. / Sravnitel'naia farmakologicheskaia kharakteristika peptidov semeistva atrial'nogo natriiureticheskogo faktora.

Comparative antihypertensive and natriuretic activities of atrial natriuretic factor (ANF) and its nearest shortened analogues--atriopeptines (AP) were studied in vivo on narcotized rats; and their peripheral vasodilating activities were studied in vitro on isolated rings of rat's thoracic aorta. The results obtained in vivo allow a following series of comparative antihypertensive and vasodilating activity: alpha rANF greater than APII greater than AP7-27. alpha rANF, APIII and APII did not differ significantly in vasodilating activity on isolated vessels; analogue 7-27 was less active. Thus further search of highly active shortened atriopeptin analogues is necessary for developing new drugs on their basis.