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Int J Gynaecol Obstet ; 129(1): 13-6, 2015 Apr.
Article in English | MEDLINE | ID: mdl-25585859

ABSTRACT

OBJECTIVE: To evaluate whether carriers of group B streptococcus (GBS) have adverse obstetric and neonatal outcomes when preterm premature rupture of membranes (PPROM) occurs. METHODS: In a retrospective study, data were reviewed for women with a singleton pregnancy and PPROM before 34 weeks who attended the Meir Medical Center, Kfar Saba, Israel, between 2005 and 2012. All women received roxithromycin for 1 week, and ampicillin until GBS culture results were available. Ampicillin was continued to 1 week if the GBS culture was positive. The primary study outcome measure was the latency period (time from rupture of membranes to active/induced labor). RESULTS: Among 116 eligible patients, 21 (18.1%) were GBS carriers and 95 (81.9%) noncarriers. The latency period was 11.2 ± 18.1 days for GBS carriers versus 7.5 ± 9.6 days for noncarriers (P=0.93). However, there was a correlation between the length of ampicillin treatment and the latency period (Spearman correlation coefficient 0.7; P<0.001). There were no differences in early neonatal outcomes. CONCLUSION: GBS carriers with PPROM did not have adverse outcomes. Longer treatment with ampicillin among GBS carriers prolonged the latency period.


Subject(s)
Anti-Bacterial Agents/administration & dosage , Antibiotic Prophylaxis/statistics & numerical data , Fetal Membranes, Premature Rupture/microbiology , Labor, Obstetric/drug effects , Streptococcus agalactiae/drug effects , Adult , Ampicillin/administration & dosage , Carrier State , Female , Humans , Infant, Newborn , Infectious Disease Transmission, Vertical/prevention & control , Pregnancy , Pregnancy Complications, Infectious/microbiology , Pregnancy Complications, Infectious/prevention & control , Pregnancy Outcome , Retrospective Studies , Roxithromycin/administration & dosage , Streptococcal Infections/prevention & control , Streptococcal Infections/transmission
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