Subject(s)
Myocarditis/metabolism , Adolescent , Adult , Ceruloplasmin/analysis , Female , Fibrinogen/analysis , Glucosephosphate Dehydrogenase/blood , Glycosaminoglycans/urine , Humans , Male , Middle Aged , Myocarditis/etiology , Orosomucoid/analysis , Pharyngitis/complications , Serum Globulins/analysis , Transketolase/bloodSubject(s)
Lupus Erythematosus, Systemic/etiology , Lysosomes/immunology , Mononuclear Phagocyte System/immunology , Animals , Antibodies, Antinuclear/immunology , Antibody Formation , Antigen-Antibody Complex/immunology , Autoantibodies/biosynthesis , Autoimmune Diseases/etiology , Autoimmune Diseases/immunology , DNA/immunology , Female , Humans , Lupus Erythematosus, Systemic/immunology , Lysosomes/enzymology , Neutrophils , PregnancySubject(s)
Arthritis, Rheumatoid/metabolism , DNA/analysis , RNA/analysis , Synovial Fluid/analysis , Adolescent , Adult , Arthritis, Rheumatoid/drug therapy , Chronic Disease , Female , Humans , Male , Middle AgedSubject(s)
Cathepsins/urine , Immunosuppressive Agents/administration & dosage , Lupus Erythematosus, Systemic/urine , Nephritis/urine , Orosomucoid/urine , Azathioprine/administration & dosage , Chlorambucil/administration & dosage , Cyclophosphamide/administration & dosage , Drug Therapy, Combination , Humans , Lupus Erythematosus, Systemic/drug therapy , Nephritis/drug therapySubject(s)
Glycosaminoglycans/urine , Rheumatic Heart Disease/urine , Acute Disease , Adolescent , Adult , Chronic Disease , Female , Humans , Male , Middle AgedSubject(s)
Arthritis, Rheumatoid/blood , DNA/blood , RNA/blood , Adult , Aged , Arthritis, Rheumatoid/diagnosis , Female , Humans , Middle AgedSubject(s)
Rheumatic Heart Disease/metabolism , Acid Phosphatase/blood , Adolescent , Adult , Alpha-Globulins/analysis , Cathepsins/blood , DNA/blood , Female , Glycoproteins/blood , Hexosamines/urine , Humans , Male , Middle Aged , RNA/blood , Uronic Acids/urineABSTRACT
Content of haptoglobin and ceruloplasmin was estimated in blood serum of 23 patients with sclerodermia systematica. A statistically distinct decrease in ceruloplasmin concentration was observed in blood of the patients, whereas content of haptoglobin was markedly increased; this phenomenon reflects a level of the pathological process activity. The proteins are synthesized in various zones of liver lobes: haptoglobin--in the central zone, ceruloplasmin - in the peripheral one. Decrease in content of ceruloplasmin in blood of patients with sclerodermia systematica was due to impairment of hepatocytes, localized in peripheral parts of liver lobes.
Subject(s)
Ceruloplasmin/analysis , Haptoglobins/analysis , Scleroderma, Systemic/blood , Animals , Carbon Tetrachloride Poisoning/blood , Chemical and Drug Induced Liver Injury/blood , Humans , RabbitsSubject(s)
DNA/blood , RNA/blood , Rheumatic Diseases/diagnosis , Adult , Female , Humans , Male , Rheumatic Diseases/bloodABSTRACT
In patients with active rheumatism the activity of the key enzymes of the pentose cycle -- glucoso-6-phosphatedehydrogenase and transketolase -- increases in the erythrocytes of the peripheral blood parallel with the severity of the inflammatory lesion of the heart. In patients with distrophic changes in the myocardium without concomitant carditis the level of glucoso-6-phosphatedehydrogenase did not change significantly, while the content of transketolase decreased considerably. Antirheumatic therapy helping to reduce the inflammatory reactions in the heart results in a reduction of the level of pentose cycle enzymes. The study of the ratio between glucoso-6-phosphatedehydrogenase and transketolase may prove valuable for an approximate evaluation of the predominance of inflammatory or dystrophic processes in the cardiac muscle.
