ABSTRACT
INTRODUCTION: Typhi is one of the rickettsial species endemic in the Mediterranean countries and is associated with the zoonotic infection of murine typhus, which may have a complicated course especially in adult patients. The association with macrophage activation syndrome (MAS) has rarely been reported in the medical literature. CASE REPORT: We describe a case of murine typhus in a diabetic woman complicated with MAS, who was effectively treated with cyclin and parenteral immunoglobulin. CONCLUSION: The murine typhus can be exceptionally complicated with SAM. This infection should be suspected in front of the discovery of SAM.
Subject(s)
Macrophage Activation , Typhus, Endemic Flea-Borne/complications , Adrenal Cortex Hormones/therapeutic use , Anemia/etiology , Anemia/therapy , Antibodies, Bacterial/blood , Blood Component Transfusion , Diabetes Mellitus, Type 2/complications , Doxycycline/therapeutic use , Drug Therapy, Combination , Exanthema/etiology , Female , Fever/etiology , Humans , Immunoglobulins, Intravenous/therapeutic use , Middle Aged , Retinitis/etiology , Rickettsia typhi/immunology , Syndrome , Thrombocytopenia/etiology , Thrombocytopenia/therapy , Typhus, Endemic Flea-Borne/diagnosis , Typhus, Endemic Flea-Borne/drug therapy , Typhus, Endemic Flea-Borne/immunology , Typhus, Endemic Flea-Borne/microbiologyABSTRACT
Gougerot Sjögren syndrome is rare during childhood. Diagnosis in adult patients is usually based on sets of criteria combining clinical, serological, and salivary gland histopathological findings. In the pediatric age group, clinical manifestations might be different from the adult form. We report on 3 cases of childhood Gougerot Sjögren syndrome.
