Subject(s)
Hypothalamic Diseases/diagnosis , Puberty , Adolescent , Adult , Female , Follow-Up Studies , Humans , Hypothalamic Diseases/complications , Hypothalamic Diseases/therapy , Male , Prognosis , Recurrence , Remission, Spontaneous , SyndromeSubject(s)
Hypothalamic Diseases/physiopathology , Islets of Langerhans/metabolism , Puberty , Adolescent , Adult , Female , Glucagon/blood , Humans , Hyperinsulinism/blood , Hyperinsulinism/physiopathology , Hypothalamic Diseases/blood , Insulin Antibodies/analysis , Male , Obesity/blood , Obesity/physiopathology , Somatostatin/blood , SyndromeSubject(s)
Hyperprolactinemia/blood , Hypothalamic Diseases/blood , Puberty , Adolescent , Adult , Disease Susceptibility , Female , Humans , Male , Obesity/blood , Prolactin/blood , SyndromeSubject(s)
Gonadal Steroid Hormones/blood , Gonadotropins, Pituitary/blood , Hypothalamic Diseases/blood , Puberty , Adolescent , Adult , Female , Humans , SyndromeSubject(s)
Hypothalamic Diseases/diagnosis , Puberty , Adolescent , Adrenocorticotropic Hormone/blood , Adult , Aldosterone/blood , Female , Humans , Hydrocortisone/blood , Hypothalamic Diseases/etiology , Hypothalamic Diseases/physiopathology , Hypothalamo-Hypophyseal System/physiopathology , Male , Obesity/diagnosis , Obesity/etiology , Obesity/physiopathology , Pituitary-Adrenal System/physiopathology , SyndromeABSTRACT
The STH level was studied in the blood of 105 patients with the hypothalamic pubertal syndrome (HPS). A tendency toward STH hyperproduction was revealed. A comparison of the STH level in the blood and the degree of obesity of the HPS patients showed a clear decrease of the growth hormone in Stage IV obesity. The STH level was almost the same in Stages I, II, III obesity. The STH secretion in the HPS patients correlated with age. The period of disease did not influence hypophysial somatotropic function in the HPS patients. No interrelationship between the content of hydrocortisone and STH in the blood was established. In most of the patients with the HPS, the growth hormone secretion in response to hypoglycemia was undisturbed. Preliminary results obtained with parlodel tests showed an opposite reaction in the HPS patients as compared to healthy ones. Our results confirmed once more that the HPS should not be interpreted as a variant of Icenko-Cushing's syndrome or constitutional obesity in which STH production was lowered.
Subject(s)
Growth Hormone/blood , Hypothalamic Diseases/blood , Pituitary Gland/metabolism , Puberty , Adolescent , Adult , Aging , Bromocriptine , Chronic Disease , Female , Humans , Hydrocortisone/blood , Insulin , Male , Obesity/blood , SyndromeSubject(s)
Hypogonadism/physiopathology , Hypopituitarism/physiopathology , Hypothalamo-Hypophyseal System/physiopathology , Pituitary Gland, Anterior/physiopathology , Puberty, Delayed/etiology , Adolescent , Adult , Follicle Stimulating Hormone/blood , Humans , Luteinizing Hormone/blood , Luteinizing Hormone/deficiency , MaleSubject(s)
Hormones/physiology , Obesity/etiology , Adrenal Cortex Hormones/physiology , Female , Glucagon/physiology , Gonadal Steroid Hormones/physiology , Growth Hormone/physiology , Humans , Hypothalamo-Hypophyseal System/physiopathology , Insulin/metabolism , Insulin Secretion , Male , Obesity/physiopathology , Obesity/therapy , Ovary/physiopathology , Pancreatic Hormones/physiology , Pituitary-Adrenal System/physiopathology , Testis/physiopathology , Thyroid Gland/physiopathology , Thyroid Hormones/physiologySubject(s)
Hypothalamic Diseases/diagnosis , Adolescent , Child , Diagnosis, Differential , Humans , SyndromeSubject(s)
Endocrine Glands/physiology , Nervous System Physiological Phenomena , Puberty , Adolescent , Adult , Child , Female , Genitalia, Female/growth & development , Genitalia, Male/growth & development , Gonadal Steroid Hormones/physiology , Growth , Humans , Hypothalamo-Hypophyseal System/physiology , Male , Menarche , Neurosecretory Systems/physiology , Ovulation , Sex Characteristics , Sex Factors , Spermatogenesis , Thymus Gland/physiology , Thyroid Hormones/physiology , Time FactorsSubject(s)
Alcoholism/physiopathology , Endocrine Glands/physiopathology , Thyroid Gland/physiopathology , Erectile Dysfunction/etiology , Ethanol/adverse effects , Female , Humans , Hypothalamo-Hypophyseal System/drug effects , Hypothalamo-Hypophyseal System/physiopathology , Hypothalamus, Anterior/metabolism , Male , Menstruation Disturbances/etiology , Norepinephrine/metabolism , Ovary/physiopathology , Parathyroid Glands/physiopathology , Pituitary-Adrenal System/physiopathology , Testis/physiopathology , Water-Electrolyte Imbalance/etiologySubject(s)
Hypopituitarism , Adolescent , Female , Humans , Hypopituitarism/diagnosis , Hypopituitarism/therapySubject(s)
Basophils , Leukocytosis , Adolescent , Child , Cushing Syndrome/diagnosis , Diagnosis, Differential , Female , Humans , Hyperpituitarism/complications , Hyperpituitarism/physiopathology , Hypothalamo-Hypophyseal System/metabolism , Hypothalamus/physiopathology , Leukocytosis/diagnosis , Leukocytosis/etiology , Leukocytosis/therapy , Lipid Metabolism , Male , Obesity/etiology , Pituitary Gland/physiopathology , Pituitary Hormones/metabolism , Puberty , Puberty, Precocious/etiology , Syndrome , Terminology as TopicABSTRACT
The authors report the results of study of the thyroid gland function in 72 patients with dyspituitrism of the puberto-juvenile period; the thyrotropic activity of the hypophysis was also studied in 37 of these patients. It was revealed that the TTH level could change both in the direction of decrease and of elevation; the inorganic phase of the iodine metabolism was reduced and the organic one--elevated. Such disproportion between the inorganic and organic phases of iodine metabolism in this disease was attributed to the hormonal disbalance, the excess in the organism of glucocorticoids and estrogens.
