ABSTRACT
Probiotic intervention may have a promising role in the prevention of AR, in preventing allergic diseases including AR. Probiotics can exert beneficial effects on the host through distinct cellular and molecular pathways, these mechanisms of action may vary from one kind of probiotic to another for the same immune response and may be regulated by a combination of several events. Material and methods- Research site-Tertiary Care Government Hospital and Medical College in a major metropolitan city.TYPE OF STUDY-Prospective comparative Study.No. of Subjects -100 cases.Study Duration-Duration for collection of data-24 months.Sample size -100 patientsData Collection:Was collected from data of case proforma of all patients.Mode of Selection -Patients presenting in Out Patient Department (OPD)and In PatientDepartment(IPD) who meet the inclusion criteria and who consent to be a part of the study.Results-Significant difference was found in 12 weeks of treatment among group A and group B. Mild symptoms were seen more after 12 weeks in group B while severity of symptom reduction was less in group A as compared to group B in 12 weeks of treatment.Conclusion Probiotic intervention may have a promising role in the prevention of AR, in preventing allergic diseases including AR.Probiotics can exert beneficial effects on the host through distinct cellular and molecular pathways, these mechanisms of action may vary from one kind of probiotic to another for the same immune response and may be regulated by a combination of several events. Thus making probiotics' mechanism of action a challenging, complex, and fertile area for investigation. Probiotics appear to prevent allergy recurrences, alleviate the severity of symptoms and improve the quality of life of patients with allergic rhinitis.
ABSTRACT
PURPOSE OF THE STUDY: Rutin (RUT) and quercetin (QRT) which are dietary compounds were investigated for their ability to protect against ionizing radiation (IR)-induced genotoxicity in human lymphocytes. MATERIALS AND METHODS: The radiation antagonistic potential of RUT and QRT was assessed by alkaline comet and cytokinesis-block micronucleus (CBMN) assay. RESULTS: Treatment of lymphocytes with RUT and QRT (25 µg/ml) prior exposure to 2 Gy gamma radiation resulted in a significant reduction of frequency of micronuclei as compared to the control set of cells evaluated by CBMN assay. Similarly, treatment of lymphocytes with RUT and QRT before radiation exposure showed significant decrease in the DNA damage as assessed by comet parameters, such as percent tail DNA and olive tail moment. CONCLUSION: The study demonstrates the protective effect of RUT and QRT against IR-induced DNA damage in human lymphocytes, which may be partly attributed to scavenging of IR-induced free radicals and also by the inhibition of IR-induced oxidative stress.
