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J Eur Acad Dermatol Venereol ; 29(7): 1435-8, 2015 Jul.
Article in English | MEDLINE | ID: mdl-25088925

ABSTRACT

BACKGROUND: Few published data, concerning the electron microscopy findings of idiopathic guttate hypomelanosis have been published so far. OBJECTIVES: To reveal the electron microscopic findings of idiopathic guttate hypomelanosis and their aetiopathogenetic associations. METHODS: Punch biopsy specimens from four patients with idiopathic guttate hypomelanosis, after being properly processed, were observed under the electron microscope. RESULTS: In the epidermis, melanocytes and melanosomes were normal in structure. In some areas, there was a reduced uptake of melanosomes by the keratinocytes. In the dermis, fibroblasts were structurally normal. Also, most elastic and collagen fibres were normal, but there were focal elastotic changes. CONCLUSIONS: No significant structural abnormality of the melanocytes was observed, but rather a functional defect in the transfer of melanosomes from the melanocytes to the keratinocytes.


Subject(s)
Hypopigmentation/pathology , Keratinocytes/ultrastructure , Melanocytes/ultrastructure , Microscopy, Electron/methods , Skin/pathology , Adult , Aged , Biopsy , Diagnosis, Differential , Female , Humans , Male , Middle Aged
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