1.
J Am Chem Soc
; 124(31): 9032-3, 2002 Aug 07.
Article
in English
| MEDLINE
| ID: mdl-12148990
ABSTRACT
A convergent synthesis of a pyrimidine core has been achieved. Treatment of alpha,alpha-dibromo oxime ethers, which are easily derived from the corresponding esters, with a variety of Grignard reagents provides trisubstituted pyrimidines in good yields. This new method offers an easy access to functionalized pyrimidines.