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1.
Hum Pathol ; 37(3): 339-44, 2006 Mar.
Article in English | MEDLINE | ID: mdl-16613329

ABSTRACT

In this report, we presented 3 cases of unusual hamartomatous nodules of the liver. These nodules were located around hepatic capsule of the left hepatic lobe and characteristically protruded from the liver. Histologically, these nodular lesions consisted of ductal structures, periductal glands, and fibrous connective tissues containing blood vessels. Smooth muscle bundles focally surrounded ductal structures. Bile-like materials were observed within some ducts. Two cases were associated with xanthogranulomatous inflammation around bile-like materials, and this inflammatory process extended from ductal lumens to periductal connective tissues. In contrast, the remaining case, which was not associated with inflammation, showed a honeycomb appearance. Ductal epithelium and periductal glands resembled biliary epithelium and peribiliary glands, respectively, and they also expressed biliary-type cytokeratins such as cytokeratins 7 and 19. These nodules shared pathologic characteristics of ciliated hepatic foregut cysts, such as their location (around the falciform ligament) and periductal smooth muscle bundles, but did not fulfill the diagnostic criteria (no ciliated cells and multilocular lesions). These hamartomatous nodules of the liver did not fit into any of the described categories of hepatic nodular lesions. At present, we speculate that these lesions might be related to developmental abnormalities of the biliary tract or embryonal foregut.


Subject(s)
Bile Duct Diseases/pathology , Bile Ducts/pathology , Cysts/pathology , Hamartoma/pathology , Aged , Bile Duct Diseases/metabolism , Bile Duct Diseases/surgery , Bile Ducts/metabolism , Biomarkers/metabolism , Cysts/metabolism , Cysts/surgery , Female , Hamartoma/metabolism , Hamartoma/surgery , Humans , Keratin-7 , Keratins/metabolism , Male , Middle Aged , Treatment Outcome
2.
Clin Imaging ; 28(5): 368-71, 2004.
Article in English | MEDLINE | ID: mdl-15471671

ABSTRACT

We investigated the incidence of cancer in surgically resected 151 thyroid nodules in 101 patients according to their calcification patterns on preoperative ultrasonography (US). Calcification was detected in 57 (38%) nodules, 31 (54%) of which was histologically diagnosed as cancer. According to the calcification types, 9 of 11 nodules with microcalcifications, 15 of 29 nodules with intranodular coarse calcification, 6 of 14 nodules with peripheral calcification and 1 of 3 calcified spots without surrounding tumor were diagnosed as cancer.


Subject(s)
Calcinosis/diagnostic imaging , Thyroid Neoplasms/diagnostic imaging , Thyroid Neoplasms/pathology , Thyroid Nodule/diagnostic imaging , Adult , Aged , Calcinosis/epidemiology , Calcinosis/pathology , Diagnosis, Differential , Female , Follow-Up Studies , Humans , Incidence , Male , Middle Aged , Preoperative Care , Retrospective Studies , Risk Assessment , Sensitivity and Specificity , Thyroid Neoplasms/epidemiology , Thyroid Neoplasms/surgery , Thyroid Nodule/pathology , Thyroidectomy , Ultrasonography, Doppler
3.
Nucl Med Commun ; 25(4): 333-7, 2004 Apr.
Article in English | MEDLINE | ID: mdl-15097806

ABSTRACT

This investigation examined the role of brain perfusion single-photon emission tomography (SPET) in traumatic head injury in 35 patients. The results were compared with those of X-ray computerized tomography (CT) and magnetic resonance imaging (MRI). CT and MRI detected brain contusions in seven patients, subarachnoid haemorrhage in one patient and both in nine patients. In 16 of the 17 subjects (94%), SPET with technetium-99m-hexamethylpropyleneamine oxime (Tc-HMPAO) revealed CT/MRI-negative abnormalities, such as hypoperfusion in the contre-coup region, frontal hypoperfusion related to personality change and cerebellar hypoperfusion associated with vertigo. In two patients presenting with diffuse axonal injury in the brainstem, hypoperfusion in the frontal cortex on the affected side was observed on SPET. SPET demonstrated hypoperfusion in the adjacent cortex, with no abnormality on either CT or MRI, in six of seven patients exhibiting acute epidural haematoma. SPET failed to provide additional information in two of five patients with acute subdural haematoma and in one of two patients displaying chronic subdural haematoma. In four of nine patients with post-traumatic amnesia, SPET detected hypoperfusion in the temporal lobe, with no abnormality on either CT or MRI. In five of eight patients with vertigo, SPET detected hypoperfusion in the morphologically normal cerebellum. In seven cases involving personality change, frontal hypoperfusion was observed in four; moreover, a markedly non-homogeneous pattern was evident in the remaining three. Overall, SPET afforded additional information in 26 patients (74%). CT possesses an advantage with respect to the detection of haemorrhagic lesions. MRI provides more precise information regarding contusions and axonal injury. Frequently, SPET may be the only examination to reveal perfusion abnormalities which are related to symptoms in the absence of other objective findings, such as post-traumatic amnesia, vertigo or personality change.


Subject(s)
Brain Injuries/diagnosis , Brain/diagnostic imaging , Brain/pathology , Positron-Emission Tomography/methods , Adolescent , Adult , Brain Injuries/diagnostic imaging , Brain Injuries/pathology , Child , Contusions , Female , Hematoma/pathology , Humans , Magnetic Resonance Imaging , Male , Perfusion , Temporal Lobe/pathology , Tomography, X-Ray Computed
4.
Ann Nucl Med ; 17(6): 463-7, 2003 Sep.
Article in English | MEDLINE | ID: mdl-14575380

ABSTRACT

This investigation was conducted to determine the ability of 201Tl brain SPECT with respect to preoperative prediction of lesional aggressiveness of meningioma. Fifty-nine lesions in 42 patients were examined. Early (15 min) and late (3 h) SPECT were obtained. Early uptake ratio (ER; lesion to normal brain average count ratio), late uptake ratio (LR) and the ratio of LR to ER (L/E ratio) were calculated. Twenty-three lesions exhibited malignant features based on histologic or clinical course such as recurrence or skull invasion. Both ER and LR of malignant meningiomas were significantly higher than those in thirty-six benign lesions. Benign lesions were classified into two groups for further analysis: meningotheliomatous type, which is the most common histology, and benign lesions other than the meningotheliomatous (other benign) type. ER in other benign type was lower than the meningotheliomatous and the malignant type. LR afforded differentiation of the malignant type from the two benign types. These two benign types could be distinguished on the basis of the L/E ratio. These results indicate that high pre-operative ER and LR values in patients with meningioma are indicators of the aggressiveness of lesions, i.e., malignant meningioma, recurrence or skull invasion.


Subject(s)
Brain Neoplasms/diagnostic imaging , Meningeal Neoplasms/diagnostic imaging , Meningioma/diagnostic imaging , Tomography, Emission-Computed, Single-Photon/methods , Brain Neoplasms/pathology , Feasibility Studies , Humans , Meningeal Neoplasms/classification , Meningeal Neoplasms/pathology , Meningioma/classification , Meningioma/pathology , Middle Aged , Neoplasm Invasiveness/diagnostic imaging , Neoplasm Staging/methods , Radiopharmaceuticals , Reproducibility of Results , Sensitivity and Specificity , Thallium
5.
Ann Nucl Med ; 16(6): 417-21, 2002 Sep.
Article in English | MEDLINE | ID: mdl-12416581

ABSTRACT

UNLABELLED: This study was performed to investigate lesions with ring-like thallium-201 (201Tl) uptake and to determine whether SPECT provides any information in differential diagnosis. METHODS: A total of 244 201Tl SPECT images were reviewed. In each study, early (15 min postinjection) and late (3 hr) brain SPECT images were obtained with 111 MBq of 201Tl. The early uptake ratio (ER; lesion to normal brain average count ratio) and the late uptake ratio (LR) and the L/E ratio (ratio of LR to ER) were calculated. RESULTS: Ring-like uptake was observed in pre-therapeutic 26 SPECT images, including ten glioblastoma multiformes (ER, 3.45 +/- 0.64; LR, 2.74 +/- 0.54; L/E ratio 0.80 +/- 0.13), five meningiomas (6.48 +/- 2.34; 4.41 +/- 1.41; 0.72 +/- 0.19), four metastatic lung cancers (3.47 +/- 1.23; 2.40 +/- 0.98; 0.70 +/- 0.14), four brain abscesses (2.48 +/- 1.06; 1.59 +/- 0.30; 0.78 +/- 0.15), one invasive lesion of squamous cell carcinoma from the ethmoid sinus (1.54; 1.52; 0.99), one medulloblastoma (3.53; 3.52; 1.00) and one hematoma (3.32; 2.36; 0.71). The ER of meningioma was significantly higher than those of glioblastoma multiforme (p < 0.0005), metastatic lung cancer (p < 0.005) and brain abscess (p < 0.0005). There were no significant differences among these three entities. The LR of meningioma was significantly higher than those of glioblastoma multiforme (p < 0.005), metastatic lung cancer (p < 0.005) and brain abscess (p < 0.0001). The LR of brain abscess was significantly lower than that of glioblastoma multiforme (p < 0.05). The L/E ratio could not differentiate these four entities. CONCLUSION: High ER and high LR in a lesion with ring-like uptake is likely an indicator of meningioma. The LR of brain abscess was significantly lower than that of glioblastoma multiforme, but 201T1 SPECT has still difficulty in differentiating abscess from brain tumor.


Subject(s)
Brain Abscess/diagnostic imaging , Brain Neoplasms/diagnostic imaging , Brain/diagnostic imaging , Neoplasms, Nerve Tissue/diagnostic imaging , Thallium , Tomography, Emission-Computed, Single-Photon/methods , Adult , Aged , Brain Abscess/diagnosis , Brain Neoplasms/diagnosis , Brain Neoplasms/secondary , Carcinoma, Squamous Cell/diagnosis , Diagnosis, Differential , Ethmoid Sinus/diagnostic imaging , Female , Glioblastoma/diagnosis , Glioblastoma/secondary , Hematoma/diagnostic imaging , Humans , Intracranial Hemorrhages/diagnostic imaging , Lung Neoplasms/pathology , Lung Neoplasms/secondary , Male , Medulloblastoma/diagnosis , Medulloblastoma/secondary , Meningioma/diagnosis , Meningioma/secondary , Middle Aged , Neoplasm Invasiveness , Neoplasms, Nerve Tissue/diagnosis , Neoplasms, Nerve Tissue/secondary , Paranasal Sinus Neoplasms/diagnosis , Radiopharmaceuticals , Retrospective Studies
6.
Surg Today ; 32(10): 916-8, 2002.
Article in English | MEDLINE | ID: mdl-12376794

ABSTRACT

We report a case of multiple ileal diverticula causing an ileovesical fistula in an 85-year-old man. The patient was admitted for investigation and treatment of intractable urethrocystitis, which he had suffered for 5 years. Cystography showed an ileovesical fistula, and contrast study of the small bowel revealed about 80 diverticula in the ileum. The segment involved by diverticula was resected and a pathological diagnosis of diverticulitis leading to ileovesical fistula was confirmed. His postoperative clinical course was uneventful.


Subject(s)
Diverticulum/complications , Ileal Diseases/etiology , Intestinal Fistula/etiology , Urinary Bladder Fistula/etiology , Aged , Aged, 80 and over , Diverticulum/surgery , Humans , Ileal Diseases/complications , Ileal Diseases/diagnosis , Ileal Diseases/surgery , Intestinal Fistula/surgery , Male , Urinary Bladder Fistula/surgery
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