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Acta Otolaryngol ; 135(3): 217-25, 2015 Mar.
Article in English | MEDLINE | ID: mdl-25649881

ABSTRACT

CONCLUSION: Additional treatment with clarithromycin (CAM) reduced persistent middle ear inflammation after acute otitis media (AOM) caused by Haemophilus influenzae in children. CAM is a treatment option for persistent inflammation following AOM and to prevent continuing otitis media with effusion. OBJECTIVE: We conducted a clinical study to evaluate a new method of treatment for persistent inflammation after AOM in children. METHODS: H. influenzae-infected children with AOM were treated acutely with antimicrobial agents, after which those still demonstrating effusion of the middle ear cavity received additional treatment with carbocysteine (S-CMC) alone or S-CMC combined with clarithromycin (CAM) for 1 week. The two regimens were compared in terms of clinical effects. RESULTS: After the initial acute treatment, many patients still showed abnormal otoscopic findings. At the completion of additional treatment, there were no significant differences between the two treatment groups. However, 1 week after completion of additional treatment, the prevalence of a diminished light reflex was significantly lower in the CAM + S-CMC group than in the S-CMC group (p = 0.017). The prevalence of redness of the tympanic membrane also tended to be lower in the combined treatment group than in those receiving a single drug (p = 0.097).


Subject(s)
Anti-Bacterial Agents/therapeutic use , Clarithromycin/therapeutic use , Haemophilus Infections/drug therapy , Haemophilus influenzae , Otitis Media/drug therapy , Anti-Infective Agents, Local/therapeutic use , Carbocysteine/therapeutic use , Child , Child, Preschool , Drug Therapy, Combination , Female , Humans , Infant , Male , Otitis Media/microbiology , Treatment Failure
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