Role of probiotic as adjuvant in treating various infections: a systematic review and meta-analysis.

BACKGROUND: Research on the advantages of probiotics has attracted increasing interest based on the number of publications, products, and public awareness of their benefits. This review evaluated the role of probiotics (single and multiple regimens) as an additional regimen to treat common infectious diseases, including Helicobacter. pylori, diarrheal infections, urinary tract infections (UTIs), upper respiratory tract infections (URTIs), and HIV infections. METHODS: We searched randomized controlled trials from PubMed, Scopus, Embase, and Cochrane and identified 6,950 studies. Duplicates were removed, and titles and abstracts were filtered. Bias was evaluated using the Cochrane Risk of Bias Tool for Randomized Trials (ROB 1.0 and 2.0). The certainty of the evidence was evaluated using GRADE. Data were extracted and meta-analysis was performed using RevMan. RESULTS: A total of 32 studies were included in this study (22 H. pylori studies, 2 diarrheal infection studies, 6 UTI studies, and 2 HIV infection studies). There was no study on URTI. Probiotics, in addition to primary treatment, could improve the eradication of H. pylori versus the control (RR: 1.09; 95% CI:1.04 - 1.13, p value = 0.001) and achieve a cure range of Nugent score in UTI patients (RR 1.38; 95% CI: 1.01 - 1.89, p value = 0.04). For eradicating H. pylori infection, subgroup analysis based on the therapy regimen showed that standard triple therapy was slightly superior compared to quadruple therapy in eradicating H. pylori (RR: 1.14 vs. 1.01, respectively). Single strain probiotics showed a similar effect to multiple strain probiotic regimens (both had an RR of 1.09). The effect estimates of the use of single strain probiotics as adjuvant therapy in eradicating H. pylori and the use of probiotics in UTI had a high certainty of evidence. Meta-analysis was not performed for infectious diarrheal because there were only two eligible studies with different probiotic supplementations and outcome parameters. Nonetheless, they showed that the diarrheal incidence was lower and complete remission of diarrheal was higher after the regimen of probiotics. Similarly, a meta-analysis was not performed for HIV infection because the two eligible studies used different designs and comparators with contradicting findings. CONCLUSION: This meta-analysis showed beneficial use of single strain probiotics as adjuvant therapy in eradicating H. pylori and the use of probiotics in UTI. Probiotic supplementation might not be beneficial for patients given a quadruple therapy. Single-strain and multi-strain probiotic regimens had similar effects in increasing the eradication rate of H. pylori. Our study also suggested that the benefits of probiotics as an additional regimen in infectious diarrheal and HIV infections remain unclear; more studies are needed to confirm the benefits.

Diagnostic Accuracy of Emergency Ultrasonography Compression by Non-Radiologists or Cardiologists for Diagnosis of Deep Vein Thrombosis in Lower Extremity: An Evidence-Based Case Report.

BACKGROUND: Deep vein thrombosis (DVT) is a medical condition with dangerous complications including lung thromboembolism which can cause death. However, the disease is often neglected, leading to delays in diagnosis and treatment. Patients with lower extremity DVT clinical signs and symptoms usually cause diagnostic dilemmas, specifically for general practitioners (GP). Various diagnostic strategies have been proposed to diagnose DVT although they still have several limitations. Therefore, emergency compression US by non-radiologists or cardiologists needs to be further considered as a fast and accurate alternative. This study aimed to analyze the potency emergency compression US by non-radiologists or cardiologists to diagnose DVT in the lower extremity. METHODS: A comprehensive literature search was conducted through PubMed, Scopus, and Cochrane Library. The articles were screened based on predetermined inclusion and exclusion criteria with the keywords emergency, general practitioners, compression US, and DVT. Critical appraisal was performed using the Oxford CEEBM Critical Appraisal Tools for Diagnostic studies criteria. RESULTS: This study analyzed a total of five cross-sectional studies and one prospective cohort. The emergency compression US performed by general practitioners and emergency physicians had a sensitivity of 86-93% and specificity of 90-97.1%. This analysis produced reliable results for diagnosing DVT in bedside settings compared to compression or doppler US performed by experts. CONCLUSION: Emergency compression US performed by general practitioners and emergency physicians had great potential to be a fast and accurate method for diagnosing and excluding DVT in lower extremities. However, standardized training is necessary to produce the highest diagnostic accuracy.

Factors Associated With Vaccination Compliance in Southeast Asian Children: A Systematic Review.

Although vaccination coverage has reached a peak of 86% globally, around 19.9 million infants and children are yet to receive routine vaccinations-with Asia holding the highest prevalence of noncompliance. This implies notable gaps in vaccination coverage among some regions in the world. This study aims to analyze the factors associated with compliance toward childhood vaccination in Southeast Asia. A systematic review of observational studies was conducted using the following databases: PubMed, Scopus, and Cochrane. Included studies analyze factors affecting compliance with childhood vaccination in Southeast Asia, and assessed with Joanna Briggs Institute (JBI) and Newcastle-Ottawa Scale's criteria. Sixteen observational studies were included, with a total of 41 956 subjects, consisting of 15 cross-sectional studies and one case-control study. Our results suggested that parental personal-related, children and family status-related, socioeconomic, and health care-related factors strongly affected subjects' compliance with immunization. Prominent determinants were older maternal age, higher economics groups, parents in government or health care sectors, and frequent antenatal care visits. On the other hand, noncompliance were associated with younger age, large quantity of family members, lower economic groups, lower education, and unemployed parents. We hope that this comprehensive assessment thoroughly addresses challenges and inform strategies to raise compliance toward childhood vaccination in Southeast Asia.