ABSTRACT
Due to activation analysis involving the use of neutrons from a nuclear reactor, the concentrations of 11 trace elements: scandium, iron, cobalt, mercury, rubidium, selenium, silver, antimony, chrome, zinc and terbium in intact bone and skeletal tumors were measured. 76 specimens of bioptates and resected material of operations for bone tumors and 10 specimens of normal bone tissue obtained in autopsies of cases of sudden death were examined. The concentrations of trace elements and their dispersion patterns in tumor tissue were found to be significantly higher than those in normal bone tissue. Also, the concentrations of some trace elements in tumor differed significantly from those in normal tissue; moreover, they were found to depend on the type and histogenesis of the neoplasm.
Subject(s)
Bone Neoplasms/analysis , Trace Elements/analysis , Adolescent , Biopsy , Bone and Bones/analysis , Child , Chondroma/analysis , Chondrosarcoma/analysis , Giant Cell Tumors/analysis , Humans , Lymphoma, Large B-Cell, Diffuse/analysis , Neutron Activation Analysis/methods , Osteoma, Osteoid/analysis , Osteosarcoma/analysisABSTRACT
Neutron-activation method was employed to determine the concentration of magnium, sodium, chlorine, phosphorus and calcium in different bone tumors. In relation to normal skeletal tissue in tumor tissues higher concentrations of chlorine and sodium but lower concentrations of calcium and phosphorus were found. The greatest changes in the macromolecular content were noted in sarcoma tissues. Bone tumors differ reliably one from the other by concentrations or ratios of macroelements concentrations, this fact may be used for the differential diagnosis.
Subject(s)
Bone Neoplasms/metabolism , Adolescent , Adult , Bone and Bones/metabolism , Calcium/metabolism , Child , Chlorine/metabolism , Chondroma/metabolism , Chondrosarcoma/metabolism , Giant Cell Tumors/metabolism , Humans , Lymphoma, Large B-Cell, Diffuse/metabolism , Magnesium/metabolism , Middle Aged , Osteoma, Osteoid/metabolism , Osteosarcoma/metabolism , Phosphorus/metabolism , Sodium/metabolismABSTRACT
A method of instrumental photonuclear activational analysis is developed for estimation of nitrogen, fluorine and phosphorus in bone tissue samples. The irradiation with maximal energy 15.6 MeV, obtained on linear accelerator of electrons LUE-25 RIMR AMN USSR, was used for activation. Estimations were carried out by the relative method with recording the intensity of positron radiation of 13N, 18F and 30P in samples and standards by means of device for gamma-gamma-coincidence. In chosen regimens of the analysis the statistical errors of nitrogen and phosphorus estimation did not esceed 1.5%, of fluorine-5%; the sensitivity of the method for nitrogen was found to be 0.06% for fluorine-0.006%, for phosphorus-0.12%; on analysis of recovery the relative standard deviation in results accounted for nitrogen-5.4%, for fluorine-6.7% for phosphorus 6.2%. Correctness in concentrations of the elements, estimated by the method described, correlated with the data, obtained in activation with reactor neutrons and with 14MeV generator neutrons.
