ABSTRACT
We studied morphological structure of the kidneys in chronic endotoxemia modeled against the background of hypothyroidism. The detected changes did not differ from those under conditions of basic endotoxemia model and were characterized by the development of glomerulosclerosis and glomerulohyalinosis. The changes were less severe in rats with hypothyroidism and appeared at the late terms of the experiment. This indicated a moderate protective effect of preexisting thyroid hormone deficiency.
Subject(s)
Endotoxemia/pathology , Endotoxemia/physiopathology , Hypothyroidism/complications , Kidney/pathology , Kidney/physiopathology , Animals , Endotoxemia/complications , Enzyme-Linked Immunosorbent Assay , Male , Rats , Thyrotropin/blood , Thyroxine/blood , Triiodothyronine/bloodABSTRACT
Simulation of chronic endotoxemia in rats leads to the development of nephropathy and nephrosclerosis. Kidney involvement was more pronounced in animals with endotoxemia developing against the background of hyperthyroidism. Direct effects of bacterial LPS and its secondary effects mediated through circulating LPO products under conditions of thyroid hormone excess caused damage to the renal tissue. Immunohistochemical studies demonstrated higher expression of apoptosis markers in nephrocytes of the proximal tubules in rats with hyperthyroidism.
Subject(s)
Endotoxemia/pathology , Hyperthyroidism/pathology , Kidney/pathology , Animals , Apoptosis , Endotoxemia/physiopathology , Hyperthyroidism/physiopathology , Male , RatsABSTRACT
Experimental study of the effects of endogenous toxic compounds on endocrine organs showed that the pathomorphological changes were caused by the cytopathic effects of endogenous toxic compounds involving the development of stereotypical reactions to injury. The severity of these reactions depended on the initial functional status of the gland and its involvement in systemic mechanisms of adaptation to the toxic process.
Subject(s)
Endotoxemia/pathology , Adrenal Glands/immunology , Adrenal Glands/metabolism , Adrenal Glands/pathology , Animals , Caspase 3/metabolism , Cell Count , Edema/immunology , Endocrine System/immunology , Endocrine System/pathology , Endothelial Cells/metabolism , Endotoxemia/immunology , Female , Inflammation/immunology , Islets of Langerhans/immunology , Islets of Langerhans/pathology , Lipopolysaccharides/pharmacology , Liver/immunology , Liver/pathology , Male , Nitric Oxide Synthase Type III/metabolism , Paraventricular Hypothalamic Nucleus/immunology , Paraventricular Hypothalamic Nucleus/pathology , Pituitary Gland, Anterior/immunology , Pituitary Gland, Anterior/metabolism , Pituitary Gland, Anterior/pathology , Rats , TNF-Related Apoptosis-Inducing Ligand/metabolism , Thyroid Gland/immunology , Thyroid Gland/pathologyABSTRACT
Morphological changes in the ovaries and levels of sex hormones were studied in rats with chronic endotoxicosis. Long-term endogenous intoxication was associated with the development of sclerocystic ovary syndrome paralleled by hormone imbalance.
Subject(s)
Endotoxemia/metabolism , Gonadal Steroid Hormones/metabolism , Lipopolysaccharides/toxicity , Ovary/metabolism , Ovary/pathology , Salmonella Infections/metabolism , Salmonella typhimurium , Animals , Carbon Tetrachloride , Endotoxemia/pathology , Female , Gonadal Steroid Hormones/blood , Kidney/drug effects , Kidney/pathology , Liver/drug effects , Liver/pathology , Rats , Rats, Wistar , Salmonella Infections/pathologyABSTRACT
Dynamic studies on rats with chronic endogenous intoxication showed involvement of the thyroid hormones in modulation of liver injury. Thyroid modulation is realized as more intense induction of TNF apoptosis in the cells and stimulation of microcirculatory disorders at the expense of nitroxide synthase expression. The modulation is quantitative, augmenting liver damage.
Subject(s)
Apoptosis/drug effects , Liver Diseases/metabolism , Liver/drug effects , Liver/metabolism , Thyroid Gland/metabolism , Tumor Necrosis Factor-alpha/metabolism , Animals , Carbon Tetrachloride/administration & dosage , Carbon Tetrachloride/toxicity , Caspase 3/metabolism , Chemical and Drug Induced Liver Injury , Female , Immunoenzyme Techniques , Immunohistochemistry , Lipopolysaccharides/adverse effects , Lipopolysaccharides/toxicity , Liver/pathology , Liver Diseases/pathology , Male , Nitric Oxide Synthase Type III/metabolism , Rats , TNF-Related Apoptosis-Inducing Ligand/metabolism , Thyroid Gland/drug effects , Thyroid Hormones/blood , Thyroxine/administration & dosage , Thyroxine/toxicityABSTRACT
Chronic endotoxicosis leads to pronounced structural changes in the thyroid gland and hypothyrosis characterized by reduced weight and activity of the thyroid parenchyma.
