ABSTRACT
Histoplasmosis, seen rarely in kidney transplantracipients, can vary from an innocuous illness often misdiagnosed as tuberculosis to a severe disseminated disease with a high mortality. We describe a case with non-specific signs in whom the diagnosis was made by histopathological examination of the lesion. Prompt introduction of specific treatment led to Histoplasmosis, seen rarely in kidney transplantracipients, can vary from an innocuous illness often misdiagnosed as tuberculosis to a severe disseminated disease with a high mortality. We describe a case with non-specific signs in whom the diagnosis was made by histopathological examination of the lesion. Prompt introduction of specific treatment led to the patient making an excellent recovery the patient making an excellent recovery.
ABSTRACT
125Iodine-labelled Mycobacterium tuberculosis antigens were immunoprecipitated with tuberculosis patients' sera and analysed by sodium dodecyl sulfate polyacrylamide gel electrophoresis. A group of four polypeptide antigens of 55, 38, 28 and 18 kD were thus identified. The 38 and 28 kD polypeptides were the major antigens. Antibody response differed from one patient to another, both with respect to the number and quantity of antigens precipitated. Untreated patients and those undergoing treatment with antimycobacterial drugs also showed marked differences in their antibody response. Generally, immunoprecipitates from treated patients showed a larger number of antigen bands and the relative intensities of the bands was also greater. No correlation was observed between the immunoprecipitation profile and antibody titres determined by enzyme linked immunosorbent assay.
