[The activity of superoxide dismutase and its isoenzymes in the immunocompetent cells of the peripheral blood in systemic lupus erythematosus and rheumatoid arthritis]. / Aktivnost' superoksiddismutazy i ee izofermentov v immunokompetentnykh kletkakh perifericheskoi krovi pri sistemnoi krasnoi volchanke i revmatoidnom artrite.

General activity of superoxide dismutase (SOD) and its isoenzymic spectrum in lymphocytes and neutrophils were studied in the peripheral blood from 63 SLP and 85 RA patients. A significant decline in SOD activity and qualitative shifts in SOD isoenzymic spectrum were found in both cell groups. The differences were specific for lymphocytes and neutrophils. SOD isoenzymic aberrations proved significant in minimal activity of SLP and RA and go in the same direction in both the diseases. General SOD activity and its isoenzymic composition can serve sensitive indications of immunocompetent cell function both in SLP and RA and of the need in antioxidants inclusion into combined treatment of both the diseases.

[The possibilities for the early diagnosis of ankylosing spondylarthritis]. / Vozmozhnosti rannei diagnostiki ankiloziruiushchego spondiloartrita.

Soluble antigen HLA-B27 was assayed in blood serum of 30 patients afflicted with ankylosing spondyloarthritis (AS) and 25 healthy subjects having HLA-B27 (B27+) antigen in the phenotype. As compared to B27+ healthy subjects, B27+ patients with AS demonstrated a significantly higher level of soluble HLA-B27 antigen. A substance whose functional activity was found to be identical to that of soluble HLA-B27 antigen in blood serum of B27- patients with AS was discovered for the first time. It was absent from B27- healthy subjects. In addition to the identification of the fixed forms of soluble HLA-B27 antigen, the assay of this antigen in blood serum enhances the potentialities of laboratory diagnosis of AS, which plays an important role at the early disease stages.

[Study of isoenzymes of lymphocyte populations during controlled immunization and in autoimmune pathology]. / Issledovanie izofermentov limfotsitarnykh populiatsii v protsesse napravlennoi immunizatsii i pri autoimmunnoi patologii.

It has been shown that during immune system activation pronounced alterations are observed in the metabolic process course in lymphoid cells that, probably, reflect the changes in T- and B-lymphocyte functional activity, and the kinetics of intercellular relationships. The ratio of LDH1 and LDH5 fractions most differing in electrophoretic mobility has been recommended as a sign of B-system immunity activation.

[The function of lymphocyte populations based on aberrations in the lactate dehydrogenase isoenzyme spectra in systemic lupus erythematosus and rheumatoid arthritis]. / Izuchenie funktsional'nogo sostoianiia populiatsii limfotsitov po aberratsiiam izofermentnykh spektrov laktatdegidrogenazy pri sistemnoi krasnoi volchanke i revmatoidnom artrite.

The data were obtained on the presence of considerable aberrations of the isoenzymic spectrum of lactate dehydrogenase in different lymphocyte populations and subpopulations. The isoenzymic shifts reflect the changes occurring in the metabolic status of the cells and are sensitive tests detecting functional deficiency of lymphocytes.

[Immunopathological manifestations of systemic lupus erythematosus and their correction during long-term dispensary observation]. / Immunopatologicheskie proiavleniia sistemnoi krasnoi volchanki i ikh korrektsiia v protsesse dlitel'nogo dispansernogo nabliudeniia.

The time course of immunopathological symptoms of lupus erythematosus was studied in 117 patients over a period of 5 years. It was established that routine multimodality therapy while resulting in a positive time course of clinical and clinico-biochemical indices, did not ensure the normalization of immunological parameters, particularly of the T-system of immunity. Courses of theophylline and splenin therapy were added to multimodality therapy to raise therapeutic efficacy and to return to normal the status of the immune system. A regular follow-up made it possible to stabilize the disease in 82.1% of the LE patients and to preserve working capacity in 50.4% of them.

[HLA antigens in systemic lupus erythematosus patients]. / Antigeny sistemy HLA u bol'nykh sistemnoi krasnoi volchankoi.

A study was made of the rate of HLA system antigens in 75 patients with different clinical versions and immuno-pathological manifestations of systemic lupus erythematosus (SLE). A total of 350 normal subjects comprised the control group. During SLE, a high rate of DNW3, B8 and AI antigens was revealed. Associative relations were established between individual clinical syndromes of SLE and immuno-pathological manifestations of the disease and definite antigens of the HLA system. The results of typing HLA system antigens can be used as additional criteria of SLE diagnosis, disease prediction, and choice of adequate therapy schemes.