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Biull Eksp Biol Med ; 107(4): 451-3, 1989 Apr.
Article in Russian | MEDLINE | ID: mdl-2720164

ABSTRACT

The capability of liposomes with plant phosphatidylcholine to extract cholesterol from erythrocyte membrane was investigated. It was shown, that plant phosphatidylcholine extracted 42% of membrane cholesterol, without causing haemolysis. This cholesterol extraction was responsible for the decrease of membrane microviscosity and for the increase of Na+, K+-ATPase activity. It is suggested that it is possible to create the extractive agent of cholesterol with plant phosphatidylcholine.


Subject(s)
Anticholesteremic Agents/pharmacology , Cholesterol/isolation & purification , Membrane Lipids/isolation & purification , Phosphatidylcholines/pharmacology , Animals , Cholesterol/blood , Drug Carriers , Drug Design , Drug Stability , Emulsions , Erythrocyte Membrane/drug effects , Erythrocyte Membrane/metabolism , Liposomes , Membrane Lipids/blood , Rabbits
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