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Prikl Biokhim Mikrobiol ; 46(2): 172-9, 2010.
Article in Russian | MEDLINE | ID: mdl-20391760

ABSTRACT

The connection between the efficiency of phenolic lipids (PL) and their hydrophobic property (solubility) and hydrophobic property of microorganisms' cell structure is shown. The mixture of amphiphilic di(oxiphenil)-phenil-methanes, which act bacteriostatically under 15 mg/l, possesses maximal efficiency against Staphylococcus aureus. Against Mycobacterium smegmatis with hydrophobic cell wall, hydrophobic 2,4-dialkylocibenzol 70 mg/l was the most effective. Hexylresorcin (HR) stops the development of gram-positive bacteria in concentrations 20-50 mg/l, that of gram-negative bacteria in concentration 65 mg/l, that of M. smegmatis at 70 mg/l, and that of yeast and fungi at 300 mg/l. HR prevails bacteria spores germination in the concentration 25-100 mg/l. The dependence of antibacterial action of isomers and homologues of alkylresorcins on their structure--number, position, and length of alkyl substituents--is studied.


Subject(s)
Anti-Bacterial Agents/pharmacology , Lipids/pharmacology , Phenols/pharmacology , Anti-Bacterial Agents/chemistry , Cell Wall/chemistry , Fungi/drug effects , Gram-Negative Bacteria/drug effects , Gram-Positive Bacteria/drug effects , Lipids/chemistry , Microbial Sensitivity Tests , Mycobacterium smegmatis/drug effects , Phenols/chemistry , Resorcinols/chemistry , Resorcinols/pharmacology , Solubility , Staphylococcus aureus/drug effects
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