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1.
Ukr Biokhim Zh ; 49(4): 92-6, 1977.
Article in Ukrainian | MEDLINE | ID: mdl-197676

ABSTRACT

Adrenalectomy and administration of hydrocortisone and ACTH are shown to induce no changes in the total activity of neutral peptide-hydrolase in both homogenates and brain subcellular fractions. The absence of adrenalectomy and hormone administration effect on the total peptide-hydrolase activity in homogenates is established simultaneously with its essential changes in the brain subcellular fractions. A decrease in the enzymic activity of the mitochondrial-lysosomal fraction (MLF) following adrenalectomy is observed side by side with its increase in a soluble fraction. Hydrocortisone and ACTH administration cause an increase in the acid peptide-hydrolase activity in MLF and its decrease in the brain soluble and microsomal fractions of adrenalectomized rabbits. The degree of solubilization of MLF acid and neutral peptide-hydrolase by detergent triton X-100 after adrenalectomy is increased. Hydrocortisone and ACTH administration, on the contrary, decrease a degree of solubilization of the brain MLF peptide-hydrolase in adrenalectomized animals.


Subject(s)
Adrenalectomy , Adrenocorticotropic Hormone/pharmacology , Brain/enzymology , Hydrocortisone/pharmacology , Peptide Hydrolases/metabolism , Animals , Brain/drug effects , Lysosomes/enzymology , Male , Microsomes/enzymology , Mitochondria/enzymology , Rabbits , Solubility , Subcellular Fractions/enzymology
2.
Ukr Biokhim Zh ; 47(3): 314-8, 1975.
Article in Ukrainian | MEDLINE | ID: mdl-175533

ABSTRACT

A single introduction of hydrocortisone is established to evoke an increase in the total activity of acid peptide-hydrolase in most areas of the brain. A single administration of ACTH single and long term administration of hydrocortisone was found to increase the specific activity of acid peptide-hydrolase of the soluble fraction. The specific activity of neutral peptide-hydrolase of the soluble fraction increases with a single administration of ACTH and long term administration of hydrocortisone. A single and long term administration of hydrocortisone and ACTH cause an increase in the percentage of the soluble form of peptide-hydrolases of the total activity.


Subject(s)
Adrenocorticotropic Hormone/pharmacology , Brain/enzymology , Hydrocortisone/pharmacology , Peptide Hydrolases/metabolism , Animals , Brain/drug effects , Organ Specificity
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