ABSTRACT
Administration of angiotensin-converting enzyme inhibitor captopril inhibited the activity of renin-angiotensin system (RAS), increased leukin-enkephalin level in the hypothalamus and adenohypophysis. The data obtained suggest that the enzyme is an important link in the mechanism of interaction between the renin-angiotensin and enkephalinergic systems in rats.
Subject(s)
Brain/physiology , Hypothalamo-Hypophyseal System/physiology , Pituitary Gland/physiology , Pituitary-Adrenal System/physiology , Receptors, Opioid/physiology , Renin-Angiotensin System/physiology , Adrenalectomy , Angiotensin-Converting Enzyme Inhibitors/pharmacology , Animals , Brain/drug effects , Brain Chemistry/drug effects , Brain Chemistry/physiology , Captopril/pharmacology , Enkephalin, Leucine/analysis , Enkephalin, Leucine/drug effects , Enkephalin, Leucine-2-Alanine/analogs & derivatives , Enkephalin, Leucine-2-Alanine/pharmacology , Hypothalamo-Hypophyseal System/drug effects , Male , Pituitary Gland/drug effects , Pituitary-Adrenal System/drug effects , Rats , Rats, Wistar , Receptors, Opioid/drug effects , Renin-Angiotensin System/drug effects , Time FactorsABSTRACT
The paper is concerned with a study of the effect of an excess of corticosteroids in the body, resulting from single and multiple hydrocortisone administration to rats, on the activity of enzymes involved in the pathway of the renin-angiotensin and kinin systems in different parts of the brain and hypophysis. Hydrocortisone administration to rats resulted in an increase in the activity of the angiotensin converting enzyme in the hypothalamus, hippocamp, striate body and hypophysis, an increase in the renin-like activity in the hypothalamus and hippocamp and its decrease in the striate body. The nature of changes in kininase I activity after the hormone administration was different in the examined parts of the brain. The results obtained indicated that one of the links in the mechanism of corticosteroid action on the renin-angiotensin and kinin system of the brain was the effect of these hormones on the activity of the renin-like, angiotensin converting enzymes and kininase I.
Subject(s)
Brain/drug effects , Carboxypeptidases/metabolism , Hydrocortisone/pharmacology , Lysine Carboxypeptidase/metabolism , Peptidyl-Dipeptidase A/metabolism , Pituitary Gland/drug effects , Renin/metabolism , Animals , Brain/enzymology , Male , Pituitary Gland/enzymology , Rats , Rats, Inbred Strains , Time Factors , Tissue DistributionABSTRACT
It is shown that the activity of enzymes participating in renin-angiotensin and brain kinin systems' metabolism depends on functional state of hypothalamo-pituitary-adrenocortical system. Under experimental hypocorticism the activity of angiotensin-converting enzyme and kininase I in the hypothalamus, hippocamp, corpus striatum and rat pituitary decreases; the renin-like enzyme activity decreases in the corpus striatum but increases in the hypothalamus and hippocamp. After hydrocortisone administration to adrenalectomized rats the angiotensin-converting enzyme activity of the hippocamp and pituitary is shown to be normalized as well as renin-like enzyme and kininase I of the hippocamp and corpus striatum. The activity of the studied enzymes in the hypothalamus decreases in this case.
