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1.
Neuroradiology ; 61(9): 1093-1101, 2019 Sep.
Article in English | MEDLINE | ID: mdl-31203414

ABSTRACT

PURPOSE: Arteriosclerosis of the vascular system is associated with many accompanying diseases. Especially cerebral arteriosclerosis is a main risk factor for ischemic strokes. We want to verify the practicability of intravascular imaging like intravascular ultrasound and optical coherence tomography for the assessment of cerebral vessel walls and plaques. METHODS: We examined 18 Circuli arteriosi willisii postmortem. The data contained 48 plaques from 48 different vessel parts. The samples underwent intravascular and histological imaging to conduct a quantitative assessment of vessel wall parameters (healthy vessel wall, thinnest vessel wall, plaque thickness and vessel diameter) as well as to qualitatively evaluate the healthy vessel wall, fibrotic plaques, calcifications and cholesterol deposits in diseased vessels. RESULTS: The comparison showed statistically significant smaller measurements for thinnest vessel walls, normal vessel walls and vessel diameters in histology than in imaging. No statistically significant difference was reached for plaque diameters. Fibrotic plaques were characterized as hyper-intense with dorsal attenuation and calcifications as hypo-intense with dorsal attenuation in optical coherence tomography. In intravascular ultrasound, fibrotic plaques showed a homogeneous echogenicity without distal attenuation and calcifications were depicted as hyperechoic with dorsal sound shadows. Cholesterol deposits were hyper-intense in optical coherence tomography with strongly attenuated signals and in intravascular ultrasound; the deposits were hyper-intense with almost no attenuation. CONCLUSION: Both intravascular methods allow for plaque characterization and quantification of plaque diameter in cerebral vessel walls. When compared with histology, a statistically significant bias was obtained for the ex vivo measurements of the normal vessel wall diameters.


Subject(s)
Intracranial Arteriosclerosis/diagnostic imaging , Plaque, Atherosclerotic/diagnostic imaging , Tomography, Optical Coherence , Ultrasonography, Interventional , Aged , Cadaver , Female , Humans , Male , Middle Aged
2.
Chirurg ; 86(8): 811-22, 2015 Aug.
Article in German | MEDLINE | ID: mdl-26223666

ABSTRACT

Papillary tumors originate from the various structures of the ampulla of Vater; therefore, these rare tumors represent a heterogeneous group of tumor entities. Intestinal differentiated adenomas are the most common benign lesions, whereas intestinal differentiated papillary carcinomas are the most common malignant tumors. Carcinomas with pancreaticobiliary differentiation have a poorer prognosis. Mesenchymal and neuroendocrine tumors are among the least frequent papillary tumors. Diagnosis is performed by side-view upper endoscopy and biopsy. In cases of suspected malignancy a complete staging with computed tomography (CT) and endoscopic ultrasound scanning is indicated to determine local tumor spread.Adenomas are removed by endoscopic snare papillectomy whereas the therapy of choice for papillary carcinomas is pancreatic head resection with systematic lymphadenectomy. Patients with papillary carcinomas are most likely to benefit from adjuvant therapy, which should be determined in an interdisciplinary consensus conference considering the histological differentiation of the tumor.


Subject(s)
Adenoma/surgery , Ampulla of Vater/surgery , Carcinoma, Papillary/surgery , Common Bile Duct Neoplasms/surgery , Adenoma/diagnosis , Adenoma/mortality , Adenoma/pathology , Ampulla of Vater/pathology , Carcinoma, Papillary/diagnosis , Carcinoma, Papillary/mortality , Carcinoma, Papillary/pathology , Common Bile Duct Neoplasms/diagnosis , Common Bile Duct Neoplasms/mortality , Common Bile Duct Neoplasms/pathology , Cooperative Behavior , Humans , Interdisciplinary Communication , Neoplasm Staging , Pancreas/pathology , Pancreas/surgery , Prognosis , Survival Rate , Tomography, X-Ray Computed
3.
Pathologe ; 35 Suppl 2: 249-53, 2014 Nov.
Article in German | MEDLINE | ID: mdl-25394974

ABSTRACT

Inflammation is a hallmark in the development and progression of malignant tumors. In chondrosarcoma the inflammatory changes are relatively discrete; however, tumor-associated macrophages (TAM) may exert tumor-promoting effects. Interleukin (IL)-1 is an inflammatory cytokine which is produced by TAMs and which leads to the expression of NF-κB-regulated genes in chondrosarcoma cells, such as vascular endothelial growth factor A (VEGF-A). Through IL-1 antagonists and substances, such as curcumin IL-1-induced VEGF-A expression and angiogenesis can be blocked; therefore, IL-1-blockade provides an interesting therapy target for chondrosarcoma.


Subject(s)
Antineoplastic Agents/therapeutic use , Bone Neoplasms/drug therapy , Bone Neoplasms/genetics , Bone Neoplasms/pathology , Chondrosarcoma/drug therapy , Chondrosarcoma/genetics , Inflammation/drug therapy , Inflammation/genetics , Inflammation/pathology , Molecular Targeted Therapy , Chondrosarcoma/pathology , Gene Expression Regulation, Neoplastic/genetics , Humans , Interleukin-1/antagonists & inhibitors , Interleukin-1/genetics , Macrophages/drug effects , Macrophages/pathology , NF-kappa B/genetics , Vascular Endothelial Growth Factor A/genetics
4.
J Cancer Res Clin Oncol ; 140(9): 1457-63, 2014 Sep.
Article in English | MEDLINE | ID: mdl-24825122

ABSTRACT

BACKGROUND: The aim of the current study was to investigate the role of BRCA1 promoter methylation as predictive factor of response to platinum-taxane-based therapy in sporadic ovarian cancer. PATIENTS AND METHODS: BRCA1 promoter methylation was analyzed in 42 sporadic epithelial ovarian cancers. The results were validated in a second cohort of 137 ovarian cancer patients. RESULTS: BRCA1 promoter methylation was observed in 35.7 % of patients in the first group and in 33.6 % in the second group. BRCA1 promoter methylation was associated with significant increase in median progression-free survival (PFS) of ovarian cancer patients receiving adjuvant platinum-taxane-based chemotherapy (P = 0.008). Multivariate analysis revealed that BRCA1 promoter methylation remains a favorable factor in regard to PFS (HR 0.52; 95 % CI 0.32-0.85, P = 0.009) after adjustment for other prognostic factors. Under the patients with recurrent disease, BRCA1 promoter methylation was associated with significant longer median PFS of 18.5 months in comparison with 12.8 months PFS for patients without BRCA1 promoter methylation. CONCLUSIONS: BRCA1 promoter methylation is predictive for better response to platinum-taxane-based therapy in EOC.


Subject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , BRCA1 Protein/genetics , Biomarkers, Tumor/genetics , Neoplasms, Glandular and Epithelial/drug therapy , Neoplasms, Glandular and Epithelial/genetics , Ovarian Neoplasms/drug therapy , Ovarian Neoplasms/genetics , Promoter Regions, Genetic/genetics , Adult , Aged , Aged, 80 and over , Bridged-Ring Compounds/administration & dosage , Carcinoma, Ovarian Epithelial , Disease-Free Survival , Female , Humans , Methylation/drug effects , Middle Aged , Organoplatinum Compounds/administration & dosage , Prognosis , Taxoids/administration & dosage , Young Adult
5.
Breast Cancer Res Treat ; 141(2): 205-12, 2013 Sep.
Article in English | MEDLINE | ID: mdl-24026861

ABSTRACT

The aim of the current study was to investigate the role of BRCA1 gene aberrations in sporadic triple-negative breast cancer (TNBC) and its impact on anthracycline-based therapy. BRCA1 promoter methylation was analyzed in 70 TNBC and compared with the clinical and pathologic characteristics. As a control group, we used 70 patients with non-TNBC. BRCA1 promoter methylation was observed in 65.2 % of patients and was similar in both groups. BRCA1 promoter methylation was associated with decreased intensity of BRCA1 protein expression (P = 0.002) and significant increase of median disease-free survival (DFS) of TNBC patients receiving adjuvant anthracycline-based chemotherapy (P = 0.001). Multivariate analysis revealed that BRCA1 promoter methylation remains a favorable factor in regard to DFS (HR 0.224; 95 % CI 0.092-0.546, P = 0.001) in TNBC after adjustment for other prognostic factors. In contrast, in non-TNBC, BRCA1 promoter methylation was not associated with any clinical and pathologic parameters. BRCA1 promoter methylation is a common mechanism of BRCA1 gene aberration in sporadic breast cancer and is predictive for better response to anthracycline-based therapies.


Subject(s)
BRCA1 Protein/genetics , DNA Methylation , Promoter Regions, Genetic , Triple Negative Breast Neoplasms/genetics , Adult , Aged , Aged, 80 and over , Anthracyclines/therapeutic use , Antineoplastic Agents/therapeutic use , BRCA1 Protein/metabolism , Female , Humans , Lymphatic Metastasis , Middle Aged , Mutation , Neoplasm Grading , Prognosis , Treatment Outcome , Triple Negative Breast Neoplasms/drug therapy , Triple Negative Breast Neoplasms/mortality , Triple Negative Breast Neoplasms/pathology , Tumor Burden
6.
Pathologe ; 33(2): 124-8, 2012 Mar.
Article in German | MEDLINE | ID: mdl-22315102

ABSTRACT

The project Pathowiki (www.pathowiki.org) is a free expert database for texts, images, virtual slides and links to all subject areas of pathology in the internet. The aim of this project is to integrate all available information and media, in particular virtual microscopy, to achieve a fast overview of a relevant subject area. Here we present the project's basic functions and applications and evaluate the project with respect to the ongoing digital developments in pathology.


Subject(s)
Databases as Topic/organization & administration , Expert Systems , Internet/organization & administration , Pathology/organization & administration , Computer-Assisted Instruction , Curriculum , Education, Medical, Continuing , Germany , Humans , Pathology/education , User-Computer Interface
7.
Br J Ophthalmol ; 95(6): 876-80, 2011 Jun.
Article in English | MEDLINE | ID: mdl-21357598

ABSTRACT

AIMS: Collagen crosslinking treatment of progressive keratoconus using the photosensitiser riboflavin and ultraviolet A light of 370 nm wavelength has been shown to increase significantly the tensile strength of corneal collagen by about 300%. In keratoconus, interlamellar and interfibrillar slippage have been proposed as pathogenetic mechanisms. Therefore, the aim of this study was to assess the impact of collagen crosslinking on the interlamellar cohesive force. METHODS: 72 post mortem porcine eyes were divided into six different treatment groups: the untreated control group, the standard crosslinking group, the hypo-osmolar crosslinking group, the stromal swelling group, the formaldehyde group and the α-amylase group. An anterior 9×4 mm strip of 400 µm thickness was prepared using a lamellar rotating microkeratome. For interlamellar cohesive force measurements a splitting plane was created at 50% depth. Force-distance profiles were recorded using a microcomputer-controlled biomaterial testing machine. RESULTS: The mean interlamellar cohesive force was 0.24 N/mm in the untreated control group, 0.26 N/mm in the standard crosslinking group, 0.25 N/mm in the hypo-osmolar crosslinking group, 0.23 N/mm in hydrated corneas, 0.27 N/mm in the formaldehyde group without statistically significant difference. Only the values of the α-amylase group were statistically significantly lowered by 31.5% to 0.16 N/mm. CONCLUSIONS: Surprisingly, corneal crosslinking does not increase the interlamellar cohesive force. In the α-amylase group the cohesive force was mainly decreased because of the digestion of proteoglycans. Crosslinking seems to stabilise only inter- and intrafibrillar, but not interlamellar cohesion.


Subject(s)
Collagen/drug effects , Endothelium, Corneal/drug effects , Keratoconus/drug therapy , Photosensitizing Agents/administration & dosage , Riboflavin/administration & dosage , Tensile Strength/drug effects , Animals , Cross-Linking Reagents/administration & dosage , Endothelium, Corneal/pathology , Keratoconus/pathology , Swine , Tensile Strength/physiology , Ultraviolet Rays
8.
Ophthalmologe ; 108(2): 170-3, 2011 Feb.
Article in German | MEDLINE | ID: mdl-21161238

ABSTRACT

A 46-year-old woman presented with a 4-day history of headache, dizziness and blurred vision in the left eye and a 1-year history of neck pain. Fundoscopy revealed a pale optic disc in the left eye and a swollen optic disc in the right eye. Furthermore a bilateral anosmia was evident. Cranial magnetic resonance imaging (MRI) showed a mass in the anterior cranial fossa, which was classified as a WHO grade I endotheliomatous meningeoma. A Foster Kennedy syndrome was diagnosed.


Subject(s)
Blindness/etiology , Meningeal Neoplasms/complications , Meningeal Neoplasms/diagnosis , Meningioma/complications , Meningioma/diagnosis , Papilledema/diagnosis , Papilledema/etiology , Blindness/diagnosis , Diagnosis, Differential , Female , Humans , Middle Aged , Optic Nerve Diseases/diagnosis , Optic Nerve Diseases/etiology
9.
Pathologe ; 31 Suppl 2: 177-82, 2010 Oct.
Article in German | MEDLINE | ID: mdl-20661574

ABSTRACT

In contrast to normal cartilage, which is avascular, angiogenesis is characteristic of cartilage tumors. In this review, we outline the basic principles of angiogenesis with regard to recent findings on differential morphological and molecular aspects of angiogenesis in cartilage tumors, including enchondromas, conventional chondrosarcomas and dedifferentiated chondrosarcomas. Furthermore, we describe the effects of hypoxia and interleukin-1ß on angiogenic signaling in chondrosarcoma cells.


Subject(s)
Bone Neoplasms/blood supply , Bone Neoplasms/pathology , Cartilage Diseases/pathology , Cartilage/blood supply , Chondroma/blood supply , Chondroma/pathology , Chondrosarcoma/blood supply , Chondrosarcoma/pathology , Neovascularization, Pathologic/pathology , Cell Hypoxia/physiology , Humans , Interleukin-1beta/physiology , Signal Transduction , Vascular Endothelial Growth Factor A/physiology
10.
Eur J Cancer ; 46(3): 616-24, 2010 Feb.
Article in English | MEDLINE | ID: mdl-20004565

ABSTRACT

Chondrosarcomas are resistant to conventional chemo- and radiotherapy. A subset of chondrosarcomas arises secondarily in the benign tumour syndromes enchondromatosis (EC) and multiple osteochondromas (MO), and prevention of tumour development would greatly improve prognosis. We therefore investigated the effect of selective COX-2 inhibition on chondrosarcoma growth. COX-2 expression was studied in central- and peripheral cartilaginous tumours. The effect of COX-2 inhibition was assessed in four high-grade chondrosarcoma cell lines using celecoxib and NS-398 treatment. COX-2 activity (prostaglandin E(2) (PGE(2)) ELISA) and cell viability were measured. The (prophylactic) effect of celecoxib on chondrosarcoma growth in vivo was studied for 8 weeks using a xenograft model of cell line CH2879 in immunoincompetent nude mice. High COX-2 protein expression was mainly found in solitary peripheral chondrosarcoma and in enchondromatosis-related central chondrosarcoma, which was confirmed by qPCR. After 72h of celecoxib treatment, a significant decrease in cell viability was observed in three chondrosarcoma cell lines. In vivo, celecoxib initially slowed tumour growth in chondrosarcoma xenografts; however, after prolonged treatment relapsed tumour growth was observed. Tumour volume was negatively associated with celecoxib serum levels, and seemed smaller in the high-dose prophylactic treatment group. We confirmed the expression of COX-2 in 65% of chondrosarcomas, and COX-2 inhibition by celecoxib diminished cell viability in vitro. The initial response and the decrease in tumour volume with increased celecoxib serum levels in vivo supported a role for celecoxib, although relapsed tumour growth after 6 weeks was worrisome. Also the role of high-dose prophylactic celecoxib in preventing the development of benign and malignant cartilage tumours in EC and MO patients deserves further investigation.


Subject(s)
Antineoplastic Agents/therapeutic use , Bone Neoplasms/enzymology , Chondrosarcoma/enzymology , Cyclooxygenase 2/metabolism , Pyrazoles/therapeutic use , Sulfonamides/therapeutic use , Animals , Antineoplastic Agents/blood , Bone Neoplasms/pathology , Bone Neoplasms/prevention & control , Celecoxib , Cell Survival/drug effects , Chondrosarcoma/pathology , Chondrosarcoma/prevention & control , Cyclooxygenase 2 Inhibitors/blood , Cyclooxygenase 2 Inhibitors/therapeutic use , Disease Models, Animal , Drug Evaluation, Preclinical/methods , Humans , Male , Mice , Mice, Nude , Pyrazoles/blood , Sulfonamides/blood , Tumor Cells, Cultured , Xenograft Model Antitumor Assays
11.
Ophthalmologe ; 106(7): 628-31, 2009 Jul.
Article in German | MEDLINE | ID: mdl-19479266

ABSTRACT

A 44-year-old female patient reported a "black dot" which had been in front of the right eye for more than 4 days and which moved together with eye movements. The optical coherence tomography (OCT) image of the right macula showed large cystic cavities and thickening within the retinal pigment epithelium (RPE) near the fovea centralis as well as small bore cystic alterations, which indicated an event in the region of the choroid. Fluorescein angiography and indocyanine green angiography excluded choroidal neovascularization (CNV). The diagnosis revealed a broad superficial choroidal blood vessel mimicking a subretinal hemorrhage.


Subject(s)
Choroid/abnormalities , Choroid/blood supply , Myopia/diagnosis , Myopia/etiology , Vision Disorders/diagnosis , Vision Disorders/etiology , Adult , Diagnosis, Differential , Female , Humans , Retinal Hemorrhage/complications , Retinal Hemorrhage/diagnosis
12.
Dtsch Med Wochenschr ; 134(1-2): 19-22, 2009 Jan.
Article in German | MEDLINE | ID: mdl-19090447

ABSTRACT

HISTORY AND CLINICAL FINDINGS: The histological investigation of a surgical specimen (after cholecystectomy) from a 73-year-old woman revealed a poorly differentiated carcinoma with glandular structures and a lymph node metastasis. INVESTIGATIONS: Comparative immunochemistry, done to exclude metastatic growth of the previously demonstrated endometrioid ovarian carcinoma, was (1) negative for CK7 and CA125, positive for CK20, chromogranin A and synaptophysin (gall bladder and lymph node metastasis); (2) positive for CK7 and CA125, negative for CK20, chromogranin A and synaptophysin (ovary). DIAGNOSIS: The tumor lesion within the gall bladder and lymph node was classified as a neuroendocrine carcinoma, not a metastasis of the ovarian carcinoma. TREATMENT AND CLINICAL COURSE: The patient underwent another laparotomy with resection of the stump of the cystic duct and the liver parenchyma surrounding the former gall bladder, including dissection of the lymph nodes within the hepatoduodenal ligament. After 14 months another metastasis of the neuroendocrine carcinoma of the gall bladder was found. But for eight years there has been no recurrence of the endometrioid adenocarcinoma of the left ovary. CONCLUSION: Because of the increasing incidence of malignant diseases and second neoplasms there is a growing need for such diagnostic tests as histological and immunohistochemical analysis. This is the first case, according to the available literature, of an endometrioid adenocarcinoma of the ovary concomitant with a neuroendocrine carcinoma of the gall bladder.


Subject(s)
Carcinoma, Endometrioid/diagnosis , Carcinoma, Neuroendocrine/diagnosis , Gallbladder Neoplasms/diagnosis , Neoplasms, Second Primary/diagnosis , Ovarian Neoplasms/diagnosis , Aged , Carcinoma, Neuroendocrine/secondary , Carcinoma, Neuroendocrine/surgery , Chemotherapy, Adjuvant , Cholecystectomy, Laparoscopic , Female , Gallbladder Neoplasms/pathology , Gallbladder Neoplasms/surgery , Humans , Immunohistochemistry , Lymphatic Metastasis , Neoplasm Recurrence, Local/therapy
13.
Cytogenet Genome Res ; 119(1-2): 33-8, 2007.
Article in English | MEDLINE | ID: mdl-18160779

ABSTRACT

Lipoblastoma is a benign uncommon soft-tissue-tumor resembling fetal adipose tissue affecting mainly children under three years of age. In lipoblastoma, the typical cytogenetic changes are clonal rearrangements involving chromosomal region 8q11-->q13. The oncogene PLAG1 (pleomorphic adenoma gene 1) is located within this chromosomal region on band 8q12. Recent reports have demonstrated that in lipoblastoma, the PLAG1 gene is activated by 'promoter-swapping'. Herein, we demonstrate that in lipoblastoma, the PLAG1 gene may also be activated by low-level amplification. We report on a lipoblastoma with the karyotype 48 approximately 50,XX,del(8)(q13q21.2),+del(8)(q13q21.2)x4[cp12]. Subsequent FISH analysis on uncultured tumor cells confirmed this result and demonstrated a low-level amplification of the chromosomal region 8pter-->8q13 and 8q21.2-->8qter. A partial monosomy was seen for the chromosomal region 8q13-->8q21.2. No other gains or losses were observed by CGH analysis. RT-PCR analysis showed that the PLAG1 gene is activated in the tumor sample of the lipoblastoma analyzed, in contrast to normal fatty tissue without PLAG1 expression. In conclusion, our results demonstrate that low-level amplification is a further mechanism of PLAG1 activation in lipoblastomas.


Subject(s)
Chromosome Deletion , Chromosomes, Human, Pair 8/genetics , DNA-Binding Proteins/genetics , DNA-Binding Proteins/metabolism , Gene Amplification/genetics , Lipoma/genetics , Lipoma/metabolism , Child, Preschool , Cytogenetic Analysis , Female , Gene Expression Regulation/genetics , Humans , Karyotyping , Lipoma/pathology , Magnetic Resonance Imaging , Metaphase , RNA, Messenger/genetics
14.
Cytogenet Genome Res ; 116(1-2): 146-51, 2007.
Article in English | MEDLINE | ID: mdl-17268195

ABSTRACT

In a four-week-old child with female external and internal genitalia but with clitoris hypertrophy chromosome analysis from blood lymphocytes revealed a 46,XY karyotype. No deletion of Y chromosomal sequences was detected by PCR analysis of genomic DNA isolated from peripheral blood leucocytes. Because of the increased risk for gonadal tumours, gonadectomy was performed. Conventional cytogenetic analysis of the left dysgenetic gonad revealed a gonosomal mosaicism with a 45,X cell line in 27 of 50 metaphases. The dysgenetic left gonad demonstrated a significantly higher proportion (P = 0.005) of cells carrying a Y chromosome (46.3%) than the streak gonad from the right side (33.9%). Histomorphological examination of the left gonad revealed immature testicular tissue and rete-like structures as well as irregular ovarian type areas with cystic follicular structures. Interphase FISH analysis of the different tissues of this dysgenetic gonad demonstrated variable proportions of cells with an X and a Y chromosome. Whereas Sertoli cells and rete-like structures revealed a significantly higher proportion of XY cells in relation to the whole section of the dysgenetic gonad (P < 0.0001), almost all granulose-like cells carried no Y chromosome. The proportion of XY/X cells in theca-like cells and Leydig cells was similar to that of the whole dysgenetic gonad. In contrast to these findings, spermatogonia exclusively contained an XY constellation.


Subject(s)
Gonadal Dysgenesis/genetics , Gonads/anatomy & histology , Immunohistochemistry/methods , In Situ Hybridization, Fluorescence/methods , Sex Chromosome Aberrations , Sex Chromosomes/ultrastructure , Chromosomes, Human, X/genetics , Chromosomes, Human, Y/genetics , Female , Gonads/pathology , Humans , Infant, Newborn , Karyotyping , Sex Determination Processes
15.
Laryngorhinootologie ; 85(8): 586-8, 2006 Aug.
Article in German | MEDLINE | ID: mdl-16883494

ABSTRACT

Acinic cell carcinoma of parotid gland as cause of distant metastases are rare. The patient was a 60-year-old woman who had in 1993 a acinic cell carcinoma of right parotid gland. Tumour can be resected through total parotidectomy with facial nerve anastomosis and modified radical neck dissection (T (3) N (2b) M (0)). Since the operation the patient has remained symptom-free without any sign of tumour recurrence. After 12 years the patient noted swelling in the region of sternum and biopsy was necessary. Histologically and immunohistochemically the diagnosis of distant metastase on acinic carcinoma of the parotid gland was confirmed.


Subject(s)
Bone Neoplasms/secondary , Carcinoma, Acinar Cell/secondary , Manubrium , Parotid Neoplasms/diagnosis , Biopsy , Bone Neoplasms/diagnosis , Bone Neoplasms/pathology , Bone Neoplasms/surgery , Carcinoma, Acinar Cell/diagnosis , Carcinoma, Acinar Cell/pathology , Carcinoma, Acinar Cell/surgery , Female , Follow-Up Studies , Humans , Manubrium/pathology , Manubrium/surgery , Middle Aged , Neck Dissection , Neoplasm Staging , Osteolysis/diagnosis , Osteolysis/pathology , Osteolysis/surgery , Parotid Gland/pathology , Parotid Gland/surgery , Parotid Neoplasms/pathology , Parotid Neoplasms/surgery , Radionuclide Imaging , Reoperation , Tomography, X-Ray Computed
16.
Aktuelle Urol ; 37(4): 284-8, 2006 Jul.
Article in German | MEDLINE | ID: mdl-16878283

ABSTRACT

INTRODUCTION: Idiopathic retroperitoneal fibrosis (RPF) represents a rare inflammatory disease, which leads to extensive fibrosis of the retroperitoneal space. In the course of the progressive fibrosis, fibrous tissue compresses the retroperitoneal structures with the development of consecutive ureteral obstruction. Because of the unknown aetiology, no consensus between conservative and surgical treatment exists. CASE REPORT: A 60-year-old patient was admitted to hospital with left-sided flank pain, hydronephrosis, and retroperitoneal tumour. A CT scan-guided biopsy revealed RPF. The hydronephrosis was treated by endoluminal urinary diversion. Under simultaneous administration of steroids, an almost complete regression of the RPF was noted. CONCLUSIONS: First goal in the treatment of RPF is urinary diversion to protect the renal function. A simultaneous therapy with steroids can cause a complete regression of the RPF. Surgical intervention is only recommended in refractory cases.


Subject(s)
Retroperitoneal Fibrosis , Adrenal Cortex Hormones/therapeutic use , Biopsy, Needle , Humans , Hydronephrosis/etiology , Hydronephrosis/therapy , Male , Middle Aged , Radiography, Abdominal , Remission Induction , Retroperitoneal Fibrosis/complications , Retroperitoneal Fibrosis/diagnosis , Retroperitoneal Fibrosis/diagnostic imaging , Retroperitoneal Fibrosis/drug therapy , Retroperitoneal Fibrosis/pathology , Tomography, X-Ray Computed , Treatment Outcome , Ureteral Obstruction/etiology , Ureteral Obstruction/therapy , Urinary Diversion
17.
Z Orthop Ihre Grenzgeb ; 144(2): 223-7, 2006.
Article in German | MEDLINE | ID: mdl-16625455

ABSTRACT

Extra-abdominal aggressive fibromatosis is a benign fibroblastic neoplasia with an infiltrative nature and a high tendency of local recurrence. Here, we report on a very rare case of multicentric fibromatosis. Low complaints led to considerable size of the tumours. The aim of the multimodal treatment was a limb salvage procedure. Adjuvant radiation therapy and chemotherapy was necessary because of the renunciation of wide resections in favour of the functionality of the limb.


Subject(s)
Fibroma/diagnosis , Fibroma/surgery , Leg/surgery , Limb Salvage , Soft Tissue Neoplasms/diagnosis , Soft Tissue Neoplasms/surgery , Abdomen , Adult , Chemotherapy, Adjuvant , Combined Modality Therapy , Female , Humans , Radiotherapy, Adjuvant , Rare Diseases/diagnosis , Rare Diseases/surgery , Treatment Outcome
18.
Pathologe ; 27(3): 222-7, 2006 May.
Article in German | MEDLINE | ID: mdl-16133160

ABSTRACT

Virtual microscopy has advanced considerably and is bound to be integrated into routine diagnostics in the very near future. Its integration into existing information systems builds up digital pathology. In this review, we present details, advantages and limitations of this novel technology and describe solutions regarding its adaptation to routine workflow. The chief aim is to define an uniform data format for virtual specimens to guarantee an interoperability between different systems. In the long term, digital archives and networks will be established that will allow for a worldwide access to virtual specimens.


Subject(s)
Microscopy/methods , Pathology/methods , User-Computer Interface , Humans , Microscopy/trends , Pathology/trends
19.
Chemotherapy ; 52(1): 12-5, 2006.
Article in English | MEDLINE | ID: mdl-16340191

ABSTRACT

BACKGROUND: Cancer of unknown primary site also designated as CUP syndrome usually presents as metastatic disease with a poor prognosis and low remission as well as survival rates. CASE: We report a 46-year-old male with para-aortal and left-sided cervical lymph node metastases. Histological examination of a cervical lymph node revealed papillary carcinoma. Despite thorough investigation, no primary tumor was found. The patient was empirically treated with six courses of the FACP regimen (5-fluorouracil, Adriamycin, cyclophosphamide and cisplatin) combined with radiotherapy (40 Gy) and has remained in complete remission for 124 months. CONCLUSION: This case indicates that treatment of a patient with cancer of unknown primary site may be rewarded by a benign course. However, complete cure remains a very rare event in CUP. Remission can be achieved with a platinum-containing regimen combined with radiotherapy.


Subject(s)
Carcinoma/drug therapy , Carcinoma/pathology , Neoplasms, Unknown Primary/drug therapy , Neoplasms, Unknown Primary/pathology , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Cisplatin/therapeutic use , Cyclophosphamide/therapeutic use , Doxorubicin/therapeutic use , Humans , Lymph Nodes/pathology , Male , Middle Aged , Remission Induction , Tegafur/therapeutic use , Time Factors , Tomography Scanners, X-Ray Computed
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