Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Prostate ; 29(4): 231-40; discussion 241-2, 1996 Oct.
Article in English | MEDLINE | ID: mdl-8876706

ABSTRACT

BACKGROUND: Controversy regarding the relative efficacy of treatments for the relief of the symptoms of benign prostatic hyperplasia (BPH). METHODS: This was a 6-month double-blind randomized equivalence study that compared the effects of a plant extract (320 mg Permixon) with those of a 5 alpha-reductase inhibitor (5 mg finasteride) in 1,098 men with moderate BPH using the International Prostate Symptom Score (IPSS) as the primary end-point. RESULTS: Both Permixon and finasteride decreased the IPSS (-37% and -39%, respectively), improved quality of life (by 38 and 41%), and increased peak urinary flow rate (+25% and +30%, P = 0.035), with no statistical difference in the percent of responders with a 3 ml/sec improvement. Finasteride markedly decreased prostate volume (-18%) and serum PSA levels (-41%); Permixon improved symptoms with little effect on volume (-6%) and no change in PSA levels. Permixon fared better than finasteride in a sexual function questionnaire and gave rise to less complaints of decreased libido and impotence. CONCLUSIONS: Both treatments relieve the symptoms of BPH in about two-thirds of patients but, unlike finasteride, Permixon has little effect on so-called androgen-dependent parameters. This suggests that other pathways might also be involved in the symptomatology of BPH.


Subject(s)
Androgen Antagonists/therapeutic use , Phytotherapy , Plant Extracts/therapeutic use , Prostatic Hyperplasia/drug therapy , Aged , Aged, 80 and over , Androgen Antagonists/adverse effects , Cholestenone 5 alpha-Reductase , Double-Blind Method , Enzyme Inhibitors/therapeutic use , Finasteride/therapeutic use , Humans , International Cooperation , Male , Middle Aged , Oxidoreductases/antagonists & inhibitors , Plant Extracts/adverse effects , Prostate/drug effects , Prostate/pathology , Prostatic Hyperplasia/pathology , Prostatic Hyperplasia/physiopathology , Serenoa , Sexual Behavior/drug effects , Treatment Outcome
SELECTION OF CITATIONS
SEARCH DETAIL
...