[An evaluation of the efficacy of Pimafucin in candidiasis of the skin and mucous membranes]. / Otsenka éffektivnosti pimafutsina pri kandidozakh kozhi i slizistykh obolochek.

Results were studied of use of different dosage forms of pimafucin in candidiases in children. It was found out that the above medicinal agent is an effective anticandidiasis drug that can easily be tolerated by children. A beneficial clinical effect was noted in treatment of candidiasis complications in those children suffering from atopic dermatitis. The above drug can, we believe, come into widespread use in pediatric dermatovenereology.

[Experience in introducing the method of placental therapy in vitiligo in Ukraine]. / Opyt vnedreniia metoda platsentarnoi terapii vitiligo v Ukraine.

The preparation "melagenin" stimulating reproduction of melanocytes and synthesis of melanotic pigment was isolated from human placenta in Cuba. As many as 366 pediatric patients with vitiligo who ranged from 4 to 15 years old were followed up for 1 year. In 62 cases the area of depigmentation amounted to 71 to 100%. Treatment with melagenin proved to be effective in 83% of vitiligo patients. Indications and contraindications have been determined.

[The determination of T-lymphocyte antigenic markers in the serum of patients with atopic dermatitis]. / Vyznachennia antigennykh determinant, prytamannykh T-limfotsytam, u syrovattsi krovi khvorykh na atopichnyi dermatyt.

The euglobulin fraction of serum of the patients with atopic dermatitis was studied using monoclonal antibodies OKT3, OKT8 and OKT10 in assay system including secondary 125J labeled anti-mouse IgG antibodies. It was shown that CD3, CD8 and CD38 T-cell marker antigens shed from the T-cell surface could be found in euglobulin fraction of serum patients. The patients with atopic dermatitis successfully treated with immunomodulator vilosen were selected and their serums obtained before and after treatment were investigated. The treatment resulted in the increase of CD8, CD3 determinants and a decrease of antigens determined by OKT10 antibodies (CD38). It is supposed that an increase of CD3 and CD8 determinants is caused by stimulation of T-lymphocyte proliferation and suppressor cell function by vilosen. Since CD38 marker is predominantly on the surface of immature and activated T-cells, which do not occur in circulating blood, it can be supposed that decrease of CD38 in the euglobulin fraction of serum reflects a shedding of these determinants from T-cells of thymus and peripheral lymphoid organs.

[Hepatobiliary system function in atopic dermatitis patients]. / Sostoianie gepatobiliarnoi sistemy u bol'nykh atopicheskim dermatitom.

A total of 300 patients with atopic dermatitis were examined for the status of their gastrointestinal tract, liver and pancreas functioning. Besides clinical and laboratory studies, ultrasonic scanning of the liver and pancreas, fibrogastroduodenoscopy, radioimmunoassay of serum trypsin, C peptide, insulin, cholylglycine, radionuclide hepatography, and gamma pancreatoscintigraphy were carried out. Analysis of the findings permit a conclusion that chronic pancreatitis and impaired function of the liver and bile excretion are quite frequent in atopic dermatitis patients.

[Experience in treating atopic dermatitis in children with vilozen]. / Opyt lecheniia atopicheskogo dermatita u detei vilozenom.

The authors present data on the treatment of 150 children with atopic dermatitis. The patients were examined by related specialists. After complex immunological examination the patients received intranasally vilozen for two weeks. It was established that the immune state normalized as a result of the above-mentioned treatment.

[Clinical aspects of atopic dermatitis]. / Klinicheskie aspekty atopicheskogo dermatita.

Discusses the diagnostic criteria of atopic dermatitis. Basing on a review of modern literature, suggests the following diagnostic signs as the basic ones: a certain clinical picture and its age-specific features, the disease onset within the first months or years of life, polyvalency of the allergic reaction, concomitant respiratory allergies, a family history of allergies, a seasonal pattern of the disease course, immunologic shifts.

[Kyrle's disease]. / Bolezn' Kirle.

Kyrle's disease is a rare dermatosis with an unknown etiology. The disease cannot always be clinically diagnosed. A 14-year-old patient with this condition is described, in whom the diagnosis has been histologically verified.